SGER: FABRICATION AND EXPERIMENTAL TESTING OF MICROFLUIDIC DEVICES WITH INTEGRATED ELECTRODES FOR THE MANIPULATION OF BIOLOGICAL AND NON-BIOLOGICAL ANALYTES

CBET-0827242 Bennett这项研究将涉及微流体系统的制造以及悬浮液中分析物的实验测试。微生物、碳纳米管、干细胞和细菌（如枯草芽孢杆菌（炭疽））将使用带有集成电极的微流控装置进行操作。智力优势：这里介绍的研究将涉及开发一种微流控系统，该系统将能够使用电流体动力学技术在细胞水平上分析生物颗粒。这包括：（1）快速分离、检测和分析单细胞的能力将在分析化学的前沿提供突破;（2）快速检测和识别炭疽等生物战剂的能力将为国家安全和国防提供重大利益;以及（3）分离和分析干细胞的能力可以导致癌症和阿尔茨海默病治疗的重大进展。更广泛的影响：这种分离技术的发展将为发现新的生物体打开大门，并在生物战剂检测领域取得重大突破。空气和水资源的质量将通过从这些自然资源中去除污染物颗粒、细菌和病毒而得到改善。该技术将导致生物医学领域的改进，用于细胞分选和从生物悬浮液中去除杂质。这将促进对疾病的了解。此外，这项技术还将在国防、环境保护和医学领域取得重大进展。作为教育计划的一部分，来自UMBC Meyerhoff计划的有才华的少数民族群体以及国内学生将成为这项研究的目标。Meyerhoff计划是吸引和留住主要是少数民族学生的国家模式，他们将攻读数学或科学的高级学位，重点是帮助代表性不足的群体。

CBET-0827242BennettThis research will involve the fabrication of microfluidic systems as well as the experimental testing of analytes in suspension. Microscopic organisms, carbon nanotubes, stem cells, and bacteria such as bacillus subtilis (anthrax) will be manipulated using microfluidic devices with integrated electrodes.Intellectual Merit: The research presented here will involve developing a microfluidic system that will be able to analyze biological particles on the cellular level using electrohydrodynamic techniques. This includes (1) The ability to rapidly isolate, detect, and analyze single cells will provide breakthroughs on the frontiers of analytical chemistry; (2) The ability to rapidly detect and identify biowarfare agents such as anthrax will provide significant benefits to national security and defense; and (3) The ability to separate and analyze stem cells can lead to significant advances towards cures for cancer and Alzheimer's disease. Broader Impact:The development of such separation techniques will open the door for the discovery of new organisms and provide significant breakthroughs in the area of biological warfare agent detection. The quality of air and water resources will be improved by removing pollutant particles, bacteria, and viruses from these natural resources. This technology will lead to improvement in biomedical fields for cell sorting and removing impurities from biological suspensions. This will lead to advances in understanding of diseases. In addition, this technology will also provide significant advances in the areas of defense, environmental protection, and medicine. As part of the educational plan, talented underrepresented minority groups from the Meyerhoff Program at UMBC as well as domestic students will be targeted for this research. The Meyerhoff Program is a national model for attracting and retaining, primarily minority students, who will pursue advanced degrees in mathematics or science with an emphasis in helping underrepresented groups.