SGER: Developing a Catalytic Aldehyde Olefination Reaction

这个SGER项目将探索新发现的催化、高立体选择性醛烯烃反应的底物范围。虽然将醛羰基转化为C-C双键是普遍存在的有机反应，但不使用Ph3P或Bu3As的催化醛烯烃反应的开发明显缺乏。在不使用膦基和/或膦基试剂的情况下，新的催化醛烯烃反应有望成为一种更环保的反应。研究将进一步扩大催化醛烯烃反应的底物范围。设计和筛选额外的配体与不同的金属将进行，以确定新的，潜在的更活跃的催化剂。通过这个奖项，有机和大分子化学项目支持托莱多大学化学系林云明教授的研究。林云明教授的研究重点是开发新的催化方法来构建碳-碳和碳杂原子键。这种化学将有助于无害环境的化学合成方法，因为将产生较少的化学废物。这些催化方法的成功开发将对制药和农业的合成产生积极的影响。

This SGER project will explore the substrate scopes of the newly discovered catalytic, highly stereoselective aldehyde olefination reaction. While transforming an aldehyde carbonyl group into a C-C double bond is a ubiquitous organic reaction, the development of a catalytic aldehyde olefination reaction without employing either Ph3P or Bu3As is significantly lacking. Without employing the phosphine-based and/or phosphonate-based reagents, the new catalytic aldehyde olefination reaction holds great promises to become an environmentally more friendly reaction. Studies to further expand the substrate scopes of the catalytic aldehyde olefination reaction will be undertaken. Design and screening of additional ligands with different metals will be carried out to identify new, and potentially more active catalysts. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Yun-Ming Lin of the Department of Chemistry at the University of Toledo. Professor Yun-Ming Lin 's research efforts focus on the development of new catalytic methods for constructing C-C and carbon-heteroatom bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis because less chemical wastes will be produced. Successful development of the catalytic methods will have a positive impact on synthesis in the pharmaceutical and agricultural industries.