Arabidopsis 2010: Regulatory mechanisms of energy signaling in plants

项目摘要Jen SheenIOS-0843244题目：拟南芥2010：植物能量信号的调节机制光合植物是维持地球生命的主要太阳能转换器。尽管它具有根本的重要性，但人们对植物如何感知和适应日常光暗循环中的黑暗或不可预测的环境压力（这些压力会损害光合作用和呼吸作用并消耗能量供应）知之甚少。最近的研究发现，进化上保守的拟南芥蛋白激酶，KIN 10和KIN 11，控制转录的收敛重编程响应看似无关的黑暗，糖和胁迫条件。该项目旨在通过揭示保守能量传感器的多种生理和发育功能、信号联系和调控机制，建立植物能量信号的新概念框架。诱导突变转基因系将用于获得新的洞察的作用，能量信号在植物响应和适应不同的环境挑战，并在植物生长和发育。综合细胞，生物化学，遗传学和基因组学的方法将被应用于提高我们的理解的能量信号的调控机制，从传感器的活动，稳定性，定位，合作伙伴的相互作用，其下游转录因子和主要的靶基因的控制。该项目代表了一个新的研究方向，将不同的植物反应和调节整合到对植物生长和生存至关重要的会聚能量信号中。鉴于全球对开发可再生生物燃料的需求不断增加，对能源信号调节机制的研究迫在眉睫。基础研究将使有针对性的基因改造的碳分配，生长和发展，结构，压力和病原体抗性，所有主要决定因素的作物产量和可再生能源生产。该项目将为学生和博士后提供多学科和综合研究的独特培训机会，并促进妇女和少数民族科学家成为未来的研究领导者。该项目的主要研究者提供教育和推广计划，为植物社区和公众服务。选择的基因网络描述KIN 10 At 3g 01090，KIN 11 At 3g 29160，KINB 1 At 5g 21170，KINB 2 At 4g 16360，KINB 3 At 2g 28060，KINBG At 1g 09020，KING At 3g 48530拟南芥2010项目的URL http：genetics.mgh.harvard.edu/sheenweb/main_page.html

PROJECT ABSTRACTJen SheenIOS-0843244Title: Arabidopsis 2010: Regulatory Mechanisms of Energy Signaling in PlantsPhotosynthetic plants are the principal solar energy converter sustaining life on Earth. Despite its fundamental importance, little is known about how plants sense and adapt to darkness in the daily light-dark cycle or to unpredictable environmental stresses that compromise photosynthesis and respiration and deplete energy supplies. Recent studies have discovered that the evolutionarily conserved Arabidopsis protein kinases, KIN10 and KIN11, control convergent reprogramming of transcription in response to seemingly unrelated darkness, sugar and stress conditions. The project aims to build a new conceptual framework of energy signaling in plants by uncovering the diverse physiological and developmental functions, signaling links, and regulatory mechanisms of the conserved energy sensors. Inducible mutant transgenic lines will be use to gain new insight into the roles of energy signaling in plant response and adaptation to diverse environmental challenges, and in plant growth and development. Integrative cellular, biochemical, genetic and genomic approaches will be applied to enhance our understanding of the regulatory mechanisms of energy signaling from the control of sensor activity, stability, localization, partner interactions to its downstream transcription factors and primary target genes. This project represents a new line of research that integrates diverse plant responses and regulation into convergent energy signaling vital to plant growth and survival. The studies on the regulatory mechanisms of energy signaling are urgently important in light of the rising global needs in the development of renewable biofuels. The basic research will enable targeted genetic modification of carbon allocation, growth and development, architecture, and stress and pathogen resistance, all major determinants of crop yield and renewable energy production. The project will provide unique training opportunities for students and postdocs in multidisciplinary and integrative research, and promote woman and minority scientists as future research leaders. The Principal Investigator of the project offers educational and outreach programs serving the plant community and the general public.Description of the network of genes selectedKIN10 At3g01090, KIN11 At3g29160, KINB1 At5g21170, KINB2 At4g16360, KINB3 At2g28060, KINBG At1g09020, KING At3g48530URL of the Arabidopsis 2010 projecthttp://genetics.mgh.harvard.edu/sheenweb/main_page.html