CAREER: Atom Transfer Radical Addition and Cyclization Reactions in the Presence of Catalytic Amounts of Copper Complexes

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。 在这个由化学系无机、生物无机和有机化学项目资助的CAREER项目中，迪克讷大学的Tomislav Pintauer将开展研究，开发用于涉及自由基中间体的有机转化的新催化剂。 Pintauer将研究如何将对卤素原子转移具有高度活性的金属络合物与可以再生起始络合物的还原剂偶联。 以这种方式，单个金属络合物每次使用可以潜在地催化数十万个加成或环化反应。 教育计划的重点是几个重要项目，包括扩大迪克讷大学的本科生和研究生课程，包括催化科学的信息，开发关于X射线晶体学和金属络合物NMR方法的夏季迷你课程（提供给匹兹堡高等教育界），并指导少数民族高中学生。除了开发新的方法，这项拟议的研究将把催化原子转移反应从产生大量金属废物和杂质的反应转变为在百万分之一金属催化剂水平下有效发挥作用的反应。 此外，拟议的研究可以将其领域带到下一个研究水平，在那里可以发现更先进的方法，如化学选择性和立体选择性催化原子转移自由基加成和环化。 这项工作具有潜在的高影响力，应该为药物化学领域和制药行业提供显着的好处。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). In this CAREER project funded by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division, Tomislav Pintauer of Duquesne University will carry out research to develop new catalysts for organic transformations involving free radical intermediates. Pintauer will study how to couple metal complexes that are highly active for halogen atom transfer with reducing agents that can regenerate the starting complex. In this manner a single metal complex can potentially catalyze hundreds of thousands of addition or cyclization reactions per use. The educational plan focuses on a few important items including broadening the undergraduate and graduate curriculum at Duquesne University to include information about catalysis science, developing summer minicourses on x-ray crystallography and NMR methods for metal complexes (available to the Pittsburgh higher education community), and mentoring minority high school students.Besides developing new methodologies, the proposed research will transform catalytic atom transfer reactions from ones that generate large amounts of metal waste and impurities into ones that can function effectively at parts per million levels of metal catalysts. Additionally, the proposed research could take its field to the next level of study, where more advanced methods such as chemoselective and stereoselective catalytic atom transfer radical additions and cyclizations could be discovered. This work has the potential for high impact and should provide significant benefits for the medicinal chemistry field and for the pharmaceutical industry.