CAREER: Development of a High Efficiency Mass Spectrometry System

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。分析与表面化学项目支持普渡大学的郑欧阳教授探索用于质量分析的新仪器配置。采用理论建模、数值模拟和实验表征相结合的方法开发了高效离子转移和质量分析的方法和装置，挑战了商用仪器的灵敏度限制。仪器设备的改进也瞄准了质谱仪的小型化。开发的技术可能会导致灵敏度的显著提高，使新的方法能够解决生物科学中最具挑战性的问题，在生物科学中，只有极少量的样品需要超高灵敏度来分析。这项工作与分析仪器开发(AID)培训计划相结合，该计划鼓励基于仪器原型和研究的教育发展。不同背景的学生共同开发基于新分析技术的原型仪器。衍生仪器被提供给外部终端用户用于测试和开发应用程序。由此产生的教育与研究的结合说明了从学习到解决实际问题的转变，并提供了一种新的模式，用于为分析仪器研究培训年轻的仪器专家。将探索建立自我可持续的培训计划的机制。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The Analytical & Surface Chemistry Program supports this CAREER award to Professor Zheng Ouyang at Purdue University to explore new instrumentation configurations for mass analysis. Theoretical modeling, numeric simulation, and experimental characterization are used to develop methods and devices for high efficiency ion transfer and mass analysis, challenging the sensitivity limitations of commercial instruments. Instrumentation improvements also target miniaturization of mass spectrometers. Technologies developed will potentially result in significant increases in sensitivity, enabling new approaches to the most challenging problems in biological science, where ultra high sensitivity is required to analyze samples available only in extremely small amounts.This work interfaces with an Analytical Instrumentation Development (AID) Training Program which encourages educational development based on instrumentation prototyping and research. Students with different backgrounds work together to develop prototype instruments based on new analytical technology. Derived instruments are provided to outside end-users for testing and development of applications. The resulting integration of education with research illustrates the transition of learning to real problem solving and provides a test of a new model for training young instrumentalists for analytical instrumentation research. Mechanisms of building a self-sustainable training program will be explored.