RUI: New Metathesis Strategies for Organic Synthesis

该项目的重点是开发新的方法来全合成番荔枝内酯和氢化吡喃酮天然产物。拟议的策略利用了合成设计的元素(模块化、聚集性、双向和串联反应序列)，这些元素将简化并提供通往复杂分子结构的实用路线。除了这项研究为制备与生物相关的天然产物和类似物提供了潜力外，这些研究还将有助于正在进行的重要化学反应的发展。特别强调了烯烃的复分解反应，拟议的研究包括交叉、环合和串联复分解反应过程，这将拓宽这一强大的方法学的范围，并提供对复分解反应控制因素的见解。通过这一奖项，有机和高分子化学项目正在支持圣十字学院化学系教授凯文·J·奎因的研究。奎因教授的研究方向是复杂天然产品的化学合成，这是制药和农业行业中一个长期重要的领域。这项研究将为本科生同事提供一个理想的培训基础，使他们接触到广泛的实验和光谱技术，并要求他们对合成化学的概念和实践方面有一个坚实的理解。

The focus of this project is the development of novel approaches to the total synthesis of Annonaceous acetogenin and hydropyranone natural products. The proposed strategies make use of elements of synthetic design (modularity, convergency, two-directional and tandem reaction sequences) that will simplify and provide practical routes to complex molecular structures. In addition to the potential this research offers for the preparation of biologically relevant natural products and analogues, these studies will also assist the ongoing development of important chemical reactions. A particular emphasis is placed on olefin metathesis, and the proposed research includes cross, ring-closing and tandem metathesis processes that will broaden the scope of this powerful methodology and provide insights into factors governing metathesis reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin J. Quinn of the Department of Chemistry at the College of the Holy Cross. Professor Quinn's research efforts are directed at the chemical synthesis of complex natural products, an area of long-standing importance in the pharmaceutical and agricultural industries. This research will provide an ideal training ground for undergraduate coworkers by exposing them to a broad range of experimental and spectroscopic techniques and by requiring them to develop a solid understanding of conceptual and practical aspects of synthetic chemistry.