Site-isolation of catalysts within "smart" thimbles for cascade reactions and recycling

该奖项由2009年美国复苏和再投资法案（公法111-5）资助。该项目将开发使用聚合物套管现场分离市售Pd，Mn，Cr和Co催化剂的方法。 催化剂的结构将不会改变;位点隔离的方法将与已经针对其反应而不是针对位点隔离而优化的催化剂相容。 这些催化剂将被再循环并用于在反应容器中存在多于一种催化剂的顺序反应中。 多种催化剂将被添加到反应容器中，因为它们将彼此现场隔离，但有机分子将自由地与多种催化剂反应。 有了这个奖项，有机和高分子化学计划支持Ned B教授的研究。爱荷华州大学化学系的鲍登说。鲍登教授的研究工作集中在一般方法的发展，以现场隔离催化剂，而不改变其结构。 这项工作将允许催化剂被回收，产品被分离，危险金属污染物的含量非常低，并开发新的连续反应。 这项工作将对制药、农业和其他使用金属催化剂生产小分子的行业产生重要影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This project will develop methods to site-isolate commercially available Pd, Mn, Cr, and Co catalysts using polymeric thimbles. The structures of the catalysts will not be altered; the method of site-isolation will be compatible with catalysts that have been optimized for their reactions rather than optimized for site-isolation. These catalysts will be recycled and used in sequential reactions with more than one catalyst present in a reaction vessel. Multiple catalysts will be added to a reaction vessel because they will be site-isolated from each other, but organic molecules will be free to react with multiple catalysts. The mechanism of site-isolation will also be investigated.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Ned B. Bowden of the Department of Chemistry at the University of Iowa. Professor Bowden's research effort centers on the development of general methods to site-isolate catalysts without altering their structures. This work will allow catalysts to be recycled, products to be isolated with very low loadings of hazardous metal contaminants, and new sequential reactions to be developed. This work will have an important impact on pharmaceutical, agricultural, and other industries that use metal catalysts to yield small molecules.