Interparticle Nanoprobes Based on Magnetic Core@Shell Nanoparticles

纽约州立大学宾汉姆顿分校的钟传建教授得到了化学系分析与表面化学项目的支持，研究磁性核壳纳米颗粒及其组装体的颗粒间结构和性质。在此基础上，研究了制备尺寸可控的磁性纳米粒子核的方法，以及在纳米粒子表面涂覆厚度可控的Au和Ag壳的方法。该粒子将作为SERS纳米探针应用于生物识别。利用功能配体将粒子组装成有组织的结构，研究粒子核尺寸、壳组成、核壳结构、表面配体和粒子间相互作用对SERS活性的影响。该研究解决了纳米级核壳磁性粒子的需求，并具有表面生物相容性，可用于生物分子分离、药物靶向、医学诊断和生物传感。这项研究将与教育活动相结合，包括对研究生和本科生的培训，以及针对高中生的推广工作。

Professor Chuan-Jian Zhong of SUNY at Binghamton is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study the interparticle structures and properties of magnetic core-shell nanoparticles and assemblies. Methods for the synthesis of magnetic nanoparticle cores of controlled sizes, and for the subsequent coating of the particles with Au and Ag shells of controlled thickness will be developed. The particles will be used as SERS nanoprobes for application in bio-recognition. Functional ligands will be employed to assemble the particles into organized structures to investigate the effects of particle core size, shell composition, core-shell structure, surface ligands, and interparticle interactions on SERS activity. This research addresses the need for core-shell magnetic particles with nanoscale size and surface biocompatibility for applications in biomolecular separations, drug targeting, medical diagnostics, and biosensing. This research will be integrated with educational activities including training of graduate and undergraduate students, and outreach efforts directed at high school students.