New drugs for malaria that target histone deacetylases

目前还没有疟疾疫苗，目前的药物正在失效，每年导致数百万与疟疾相关的死亡。该项目的目的是开发新药来解决这一重大的全球健康问题。该项目将专注于通过靶向参与改变寄生虫基因表达的酶，以新的方式作用于现有的疟疾药物。这类酶是癌症等其他疾病的公认药物靶点。该项目的成果将包括在澳大利亚药物发现努力的基础上，在疟疾药物开发方面取得进展，从行业和其他来源获得更多资金机会，并为澳大利亚的研究、培训和能力建设做出贡献。

There is no vaccine for malaria and current drugs are failing, contributing to millions of malaria-related deaths each year. The aim of this project is to develop new drugs to address this significant global health issue. This project will focus on drugs that act in novel ways to existing malaria drugs by targeting enzymes that are involved in altering gene expression in the parasite. These kinds of enzymes are recognised drug targets in other diseases such as cancer. The outcomes of this project will include advances in malaria drug development that build on Australian drug discovery efforts, seeding further funding opportunities from industry and other sources and contributing research training and capacity building in Australia.