Transgenic technologies (P02)

CRC的几乎所有项目都使用转基因小鼠模型来阐明生物体中Ca2+信号传导的分子机制。这些转基因小鼠品系中有许多是独一无二的，只存在于我们的设施中。平台项目P02将继续1）在CRC内冷冻保存转基因小鼠品系，以保护动物免受污染、遗传漂移或事故造成的损失，2）生成Cre依赖性报告小鼠品系，3）生成条件等位基因。

Almost all projects of the CRC work with transgenic mouse models to elucidate the molecular mechanisms of Ca2+ signaling in the organism. Many of these genetically-modified mouse lines are unique and exist only in our facility. The platform project P02 will continue to 1) cryopreserve transgenic mouse strains within the CRC to protect the animals from contamination, loss due to genetic drift or accidents, 2) generate Cre-dependent reporter mouse strains and to 3) generate conditional alleles.