Synthetic Analogues of Methanobactin

该项目的主旨是制备一系列甲烷氧化菌素的合成类似物，甲烷氧化菌素是一种存在于甲烷氧化细菌中的小的含铜蛋白质，并表现出有效的抑菌活性。 几个新的家庭的铜（I）络合物含有螯合双（硒）和双（硒酮）配体将被合成的目标是理解的协调环境的影响，甲烷氧化菌素表现出细胞外铜的高亲和力。 此外，这些化合物对沙门氏菌的潜在抗菌活性。将对金黄色葡萄球菌进行研究。 该项目具有跨学科性质，从合成无机化学到微生物学，将吸引具有多种背景和兴趣的学生。有了这个奖项，无机，生物无机和有机物（IBO）计划将支持夏洛特的北卡罗来纳州大学化学系的丹尼尔·拉比诺维奇教授的研究。 拉宾诺维奇教授的研究工作在合成和结构无机和有机金属化学中心的各种硫供体配体的应用，以制备各种富硫金属生物分子的合成类似物，这些分子具有生物活性或模拟催化工业过程，如制氢。

The thrust of this project is the preparation of a series of synthetic analogues of methanobactin, a small copper-containing protein that is present in methane-oxidizing bacteria and exhibits potent bacteriostatic activity. Several new families of copper(I) complexes containing chelating bis(thione) and bis(selone) ligands will be synthesized with the goal of understanding the influence of the coordination environment on the high affinity that methanobactin exhibits for extracellular copper. In addition, the potential antibacterial activity of these compounds against S. aureus will be explored. The project is interdisciplinary in nature, ranging from synthetic inorganic chemistry to microbiology, and will attract students with a diversity of backgrounds and interests.With this award, the Inorganic, Bioinorganic and Organometallic (IBO) program is supporting the research of Professor Daniel Rabinovich of the Department of Chemistry at the University of North Carolina at Charlotte. Professor Rabinovich?s research efforts in synthetic and structural inorganic and organometallic chemistry center on the application of a variety of sulfur-donor ligands to the preparation of synthetic analogues of a variety of sulfur-rich metallobiomolecules that are biologically active or mimic catalytic industrial processes such as hydrogen generation.