Stability and Violation of the Lymphoid and Myeloid Dichotomy in the Immune System (L)

通过结合命运定位方法和细胞移植，我们可以证明组织巨噬细胞在大脑、皮肤、肺、肝脏、胰腺和脾脏中具有胚胎或胎儿起源的自主群体。尽管是髓系细胞，这些组织驻留细胞可以通过淋巴细胞命运定位标记与募集的骨髓来源的巨噬细胞区分开来。在接下来的资助期内，我们计划扩大我们的研究范围，以确定组织巨噬细胞的胚胎或胎儿前体，研究组织巨噬细胞在不同器官中的稳态，分析组织常驻和募集巨噬细胞在挑战下的贡献和功能。

By combining fate mapping approaches and cell transplantations we could demonstrate that tissue macrophages in brain, skin, lung, liver, pancreas and spleen autonomous populations of embryonic or fetal origin. Despite being myeloid lineages, these tissue-resident cells can be distinguished from recruited bone marrow-derived macrophages by a lymphoid fate mapping mark. In the upcoming funding period we plan to expand our studies to identify the embryonic or fetal precursors of tissue macrophages, investigate the homeostasis of tissue macrophages in different organs and analyze the contributions and functions of tissue resident and recruited macrophages under challenge.