Modulation of sodium/proton exchanger activity by covalent modification and protein interaction (P21)

钠/质子交换器在细胞内pH和细胞体积的基本控制中起着关键作用。它们的转运活动的精确调控是它们在广泛的生理过程中发挥不同功能的先决条件。它们的功能障碍与几种疾病有关，包括癫痫、心脏肥厚和癌症。我们的目标是阐明钠/质子交换活性的机制和结构基础，通过与调节蛋白的相互作用和共价修饰，重点是与钙信号的联系，以帮助详细了解钠/质子交换在健康和疾病中的具体功能。

Sodium/proton exchangers are key players in the essential control of intracellular pH and cell volume. The precise modulation of their transport activity is the prerequisite for their distinct functions in a broad spectrum of physiological processes. Their dysfunction is implicated in several diseases including epilepsy, cardiac hypertrophy and cancer. We aim for the elucidation of mechanism and structural basis of sodium/proton exchange activity modulated by the interaction with regulatory proteins and covalent modification with emphasis on the link to Ca2+ signaling to contribute to a detailed understanding of the specific functions of sodium/proton exchangers in health and disease.