MRI: Acquisition of a 500MHz NMR Spectrometer for Research at California State University Sacramento

该奖项由2009年《美国复苏与再投资法案》(Public Law 111-5)资助。在重大研究仪器(MRI)计划的资助下，来自加州州立大学萨克拉门托分校的凯瑟琳·D·麦克雷诺兹和同事Cynthia J.Kellen-袁、Claudia G.Lucero、James A.Miranda和John D.Spence将获得一台500 MHz核磁共振光谱仪和一台现有300 MHz光谱仪的自动取样器。该设备将支持以下方面的研究：1)糖树状大分子的合成；2)高共轭芳二炔的合成和光活性研究；3)含氮杂环的微波合成；4)乙烯基环丙烷的单环-裂解研究；5)酮基手性硅醚的合成和Kavain的全合成；6)海洋神经毒素软骨藻酸的生物化学途径的阐明。该仪器还将用于该大学不同群体的本科生和研究生的教学和培训。核磁共振光谱学是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。该仪器将成为教学和研究不可或缺的一部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Katherine D. McReynolds and colleagues Cynthia J. Kellen-Yuen, Claudia G. Lucero, James A. Miranda and John D. Spence from California State University - Sacramento will acquire a 500 MHz NMR spectrometer and an autosampler for an existing 300 MHz spectrometer. This equipment will support research in 1) the synthesis of glycodendrimers; 2) the synthesis and study of the photoreactivity of highly conjugated arenediynes; 3) the microwave synthesis of nitrogen heterocycles; 4) the study of vinylcyclopropane monoradical cyclization-fragmentation; 5) the synthesis of chiral silyl ethers from ketones and the total synthesis of kavain and 6) the elucidation of the biochemical pathway to the marine neurotoxin domoic acid. The instrumentation will also be used in teaching and training of a diverse group of undergraduate and graduate students at this university.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.