The pharmacology of attention in fronto-parietal sensory information processing (C04)

胆碱能系统在视觉皮层感觉反应的注意增强中起着重要作用。虽然以前在猕猴V1上的研究表明，M受体亚型对注意增强放电率有很大的贡献，但我们的最新结果表明，在纹外区MT并非如此。现在，我们希望使用两项有前景的技术来扩大我们的研究，以包括其他神经递质系统：微透析(具有有限的时间分辨率，以筛选最有希望的候选递质)和电化学(40赫兹结合电生理记录)，以确定注意力的神经药理学基础。

The cholinergic system plays an important role in the attentional enhancement of sensory responses in the visual cortex. Although previous work in macaque V1 has shown a strong contribution of the muscarinic receptor subtype to attentional enhancement of firing rates, our latest results suggest that this is not the case in extrastriate area MT. We now want to use two promising technologies to expand our investigation to include other neurotransmitter systems: microdialysis (with limited time resolution, to screen for the most promising transmitter candidates) and electrochemistry (at 40Hz in combination with electrophysiological recordings), in order to identify the neuropharmacological basis of attention.