EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms

动态的细胞行为决定了发育、组织稳态和再生。光学实时成像策略已经彻底改变了我们对细胞行为的看法，并强调了它们的动态性质，因此是“运动中的细胞”。这种光学成像策略也强调了在完整的复杂生物体中研究细胞行为的重要性，以及当前成像策略的时空限制。医学成像也是如此，创新的分子和功能成像技术使临床医生能够看到他所治疗的疾病，从而推动了医学成像的发展。然而，特异性和分辨率仍然存在局限性。基于我们广泛的跨学科专业知识，我们在克服这些限制方面处于独特的地位。我们的目标是通过分析日益复杂的系统来破译生物体中细胞行为的关键方面。我们的核心概念是使用和发展新的成像策略来优化时空分辨率和特异性。我们的愿景是建立一个跨学科的环境，促进基础生物医学科学和临床翻译及其相互作用，使用成像作为理解细胞行为的共同策略，无论这是在细胞或组织中，在动物模型中还是在患者中。为了促进知识转移和科学创造力，我们克服了院系之间的传统障碍，建立了一个新的“运动细胞跨院系中心”（CiMIC），该中心拥有指定的建筑和密歇根大学的资助，这是卓越集群CiM的基础。我们的理念不可或缺的是一个新的跨学院教育结构（“运动中的职业”中心），促进性别平等和多样性，并包括一个新颖的“实验医学”硕士课程，允许医科学生进入结构化的博士课程。这将促进高质量的临床研究和基础科学向临床的转化。

Dynamic cellular behaviour determines development, tissue homeostasis and regeneration. Optical live imaging strategies have revolutionised our perception of cellular behaviour and have emphasised their dynamic nature, hence "cells in motion". Such optical imaging strategies also highlight the importance of investigating cellular behaviour in intact complex organisms, and the temporo-spatial limitations of current imaging strategies to do so. The same is true for medical imaging, which has been boosted by innovative molecular and functional imaging technologies permitting the clinician to see what he treats. However, specificity and resolution remain limitations. Based on our broad interdisciplinary expertise we are in a unique position to overcome these limitations. We aim to decipher crucial aspects of cellular behaviour in organisms by analysing systems of increasing complexity. Central to our concept is the use and development of novel imaging strategies to optimise temporal-spatial resolution and specificity. Our vision is to establish an interfaculty environment promoting basic biomedical sciences and clinical translation and their interaction using imaging as a common strategy to understand cellular behaviour, regardless of whether this is in cells or tissues, in animal models or in patients. To foster knowledge transfer and scientific creativity we have overcome traditional barriers between faculties by establishing a new "Cells in Motion Interfaculty Centre" (CiMIC) with designated buildings and University of Münsters funding, which is the foundation of the Excellencecluster CiM. Integral to our concept is a new interfaculty educational structure ("Careers in Motion" Centre) that promotes gender equality and diversity, and includes a novel master in "Experimental Medicine" allowing medical students to enter into a structured PhD programme. This will bolster high-quality clinical research and translation of basic science to the clinic.