Experimental Determination of Chemical Structure in the Undergraduate Curriculum: A Data-Driven Approach

化学（12）实验结构的确定仍然超出了大多数本科生的经验，尽管X射线晶体学在材料和生物分子的理解中发挥着核心作用。仪器和计算能力的快速发展创造了既坚固耐用，允许非专家操作，又强大到足以在与教学环境兼容的时间尺度内收集数据的设备。在本科化学课程的各个层面，晶体学数据和技术的结合几乎没有模型存在。该项目的主要目标是：（1）开发一种新的模式，将结构方法整合到本科化学课程中，（2）评估学生在处理实验结构数据时的参与度和学习情况，（3）建立一个本地PUI用户组，以扩大X射线衍射方法和资源在本科课程中的整合，（4）建立互动式的网路教材，以教授结晶学对称性。智慧上的优点：这个计画是建立一个整合结构方法到大学化学课程的模式。评估正在地方、区域和国际各级进行，而项目的每个组成部分都解决了教学结构方法对高质量资源的需求。与STaRBURSTT CyberInstrumentation联盟的联系正在用于建立以前NSF支持的项目，将X射线结构方法纳入本科课程。该项目建立在PI以前的NSF-CCLI项目NSF-0536710，“视觉空间学习：基于网络的交互式对称性学习的发展”，并利用教师在合成无机化学和脂质生物化学方面的专业知识。该项目正在影响学生和教师（1）通过课程开发和实施在当地，（2）通过PUI用户组在区域，（3）在国内通过传播课程产品及其评估，（4）在国际上通过开发基于网络的资源来教授晶体学中的对称性。通过实验室练习、课程和讲习班，教师和学生正在接受晶体生长、X射线数据收集和X射线数据分析方面的培训。创建一个网络启用共享使用设施，致力于本科教育提供急需的基础设施，教学和本科研究在中央俄亥俄州地区。最后，将通过在国家会议上的介绍和在化学教育杂志上发表的方式传播课程编制项目及其评估的详细情况。

Chemistry (12)Experimental structure determination remains beyond the experience of most undergraduate students in spite of the central role X-ray crystallography plays in the understanding of materials and biomolecules. Rapid advances in instrumentation and computing power have created equipment that is both rugged enough to allow operation by the non-expert and powerful enough to collect data in a time scale compatible with a teaching environment. Few models exist for the incorporation of crystallographic data and techniques at all levels of the undergraduate chemistry curriculum. The key goals of this project are to: (1) develop a new model for integration of structural methods into the undergraduate chemistry curriculum, (2) assess student engagement and learning when working with experimental structural data, (3) establish a local PUI user group to broaden the incorporation of X-ray diffraction methods and resources into the undergraduate curriculum, and (4) create interactive web-based materials for teaching crystallographic symmetry.Intellectual Merit: The project is creating a model for integration of structural methods into the undergraduate chemistry curriculum. Assessment is occurring at the local, regional and international level while each component of the project addresses the need for high quality resources for teaching structural methods. Connections with the STaRBURSTT CyberInstrumentation Consortium are being used to build on previous NSF-supported projects for the incorporation of X-ray structural methods into the undergraduate curriculum. The project builds upon the PI's previous NSF-CCLI project NSF-0536710, "Visual-Spatial Learning: Development of an Interactive Web-Based Symmetry Tutorial," and makes use of the expertise of faculty in synthetic inorganic chemistry and lipid biochemistry.Broader Impacts: The project is impacting students and faculty (1) locally through curricular development and implementation, (2) regionally through a PUI user group, (3) nationally through dissemination of the curricular products and their assessment, and (4) internationally through the development of web-based resources for teaching symmetry in crystallography. Faculty and students are being trained in aspects of crystal growth, X-ray data collection, and X-ray data analysis through laboratory exercises, courses, and workshops. The creation of a cyber-enabled shared use facility dedicated to undergraduate education is providing much needed infrastructure for teaching and undergraduate research in the central Ohio area. Finally, the details of the curricular development project and its evaluation will be disseminated through presentations at national meetings and publication in a chemical education journal.