SBIR Phase I: Development of new materials for a low cost high throughput ion channel measurement platform

这个小企业创新研究（SBIR）第一阶段项目将支持一种新型离子通道测量平台的开发。离子通道在包括心脏和神经活动在内的广泛生理过程中起着重要作用。该技术的核心是廉价制造的离子通道生物芯片，这种芯片可以运送给最终用户并无限期储存，直到需要的时候。该平台极大地简化了离子通道测量过程，有可能显著提高吞吐量，降低成本，并消除执行这些复杂测量所需的专业知识。提出的研究将最大限度地提高生物芯片的产量，并尽量减少形成时间。本研究的更广泛影响是，吞吐量和数据质量的提高将通过降低药物开发和研发成本，在成本和护理质量方面显著影响医疗保健。数十亿美元的离子通道药物市场实际上服务不足，因为缺乏具有成本效益、高质量、高通量的筛选解决方案。该公司的低成本高通量解决方案将使离子通道筛选的成本显着下降。该技术的可存储性、可运输性和简单性也为更广泛的非专业科学受众和适合高中和大学实验室课程的低成本系统打开了离子通道测量能力。

This Small Business Innovation Research (SBIR) Phase I project will support the development of a novel ion channel measurement platform. Ion channels are important in a wide range of physiological processes including cardiac and neural activity. The technology is centered on inexpensively manufactured ion channel biochips which can be shipped to the end user and indefinitely stored until needed. This platform greatly simplifies the process of ion channel measurement, with the potential to significantly increase throughput, decrease cost, and eliminate the expertise necessary to perform these sophisticated measurements. The proposed research will maximize the biochip yield and minimize the formation time. The broader impacts of this research are that the increased throughput and data quality will significantly impact healthcare in terms of cost and quality of care by reducing drug development R&D costs. The multi-billion dollar market for ion channel drugs is actually underserved because of the lack of cost effective, high quality, high throughput screening solutions. The company's low cost high throughput solution will enable the cost of ion channel screening to significantly drop. The storability, shippability, and simplicity of the technology also opens ion channel measurement capability to a much wider, non-specialist scientific audience and a low cost system suitable for high school and college laboratory courses.