CAREER: Bimetallic Pd and Ag Catalysts for Electrophilic Trifluoromethylation and Fluorination

有了这个职业奖，化学合成计划支持哈佛大学的Tobias Ritter教授的研究。 Ritter教授将应用双核过渡金属配合物的结构和反应性的知识来开发催化碳-氟键的形成。 首先，将开发一种操作简单的合成方法来实现芳基锡烷的银催化氧化。 第二，银催化的氧化还原反应将扩展到复杂的小分子。 随后，将研究受益于两种过渡金属的氧化还原参与的其他氧化反应。 Ritter教授的研究可能会导致制备含氟有机分子的有效方法。 这些分子在新药和农用化学品的开发中受到高度追捧。 此外，它们也需要通过正电子发射断层扫描的分子成像。 Ritter教授还将发起将研究与教学交织在一起的教育项目。 其中一个项目涉及一个针对主要为代表性不足的群体服务的学校的外联方案。 Ritter教授将作为哈佛研究人员小组的一员前往不同的学校，该小组将对化学中的不同机会进行一般性介绍，然后是申请研究生院的具体指导方针。 另一个项目将侧重于与波士顿地区的当地高中生建立早期联系，并对他们进行一般的化学和科学教育。

With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Tobias Ritter of Harvard University. Professor Ritter will apply the knowledge of the structure and reactivity of binuclear transition metal complexes to the development of catalytic carbon-fluorine bond formation. First, an operationally simple synthetic methodology will be developed to effect a silver-catalyzed fluorination of arylstannanes. Second, the silver-catalyzed fluorination reaction will be extended to complex small molecules. Subsequently, other oxidation reactions will be investigated that benefit from the redox participation of two transition metals. Professor Ritter's research could lead to efficient methods for the preparation of fluorine containing organic molecules. These molecules are highly sought after in the development of new pharmaceuticals and agrochemicals. In addition, they are also needed in molecular imaging via positron-emission tomography. Professor Ritter will also initiate educational projects that interweave research and teaching. One project involves an outreach program targeting schools that serve predominantly underrepresented groups. Professor Ritter will travel to different schools as part of a panel of Harvard researchers that will give a general introduction into different opportunities in Chemistry followed by specific guidelines for applying to graduate schools. Another program will focus on establishing early contact to local high school students in the Boston area and educating them about chemistry and science in general.