MRI-R2: Acquisition of a 400 MHz NMR Spectrometer at Chicago State University

该奖项是根据2009年《美国复苏和再投资法案》(Public Law 111-5)获得的。在重大研究仪器(MRI)计划的这一奖项下，芝加哥州立大学化学和物理系的LeRoy Jones II教授及其同事Elmer J.Gentry、Asare Nkansah、Melany P.Puglisi-Wening和Felix M.Rivas将获得一台具有可变温度能力的400 MHz核磁共振光谱仪。该仪器将用于支持下列研究活动：1)用于烯烃歧化反应的手性过渡金属催化剂的制备；2)用于药物输送的树状大分子和聚合物的开发；3)抗菌肽的合成；4)抗菌化合物的合成修饰以改变光谱和效力；5)海洋植物和藻类的抗菌化学防御；以及6)坚果类中枢神经系统活性成分的分离和表征。核磁共振光谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究不可或缺的一部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor LeRoy Jones II and colleagues Elmer J. Gentry, Asare Nkansah, Melany P. Puglisi-Weening and Felix M. Rivas from the Departments of Chemistry and Physics at Chicago State University will acquire a 400 MHz NMR spectrometer with variable temperature capabilities. The instrument will be used to support research activities such as: 1) preparation of chiral transition metal catalysts for olefin metathesis reactions; 2) development of dendrimers and polymers for drug delivery; 3) synthesis of antibacterial peptides; 4) synthetic modification of antimicrobial compounds for altered spectrum and potency; 5) antimicrobial chemical defenses of marine plants and algae; and 6) isolation and characterization of the CNS-active constituents of nutmeg.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.