MRI-R2: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

该奖项是根据2009年《美国复苏与再投资法案》(Public Law 111-5)获得的。圣托马斯大学的J.Thomas Ippoliti教授及其同事Bartholomew Dahl、Thomas C.Marsh和William H.Ojala将获得一台带有自动取样器单元的400 MHz核磁共振(核磁共振)光谱仪。该仪器将用于支持下列研究活动：1)设计和合成能够附着在金属支架上的恶唑烷酮抗菌剂、光致变色萘并可生物降解的聚乳酸，2)探索在设计和合成联芳基分子开关中使用链状内酯单元，3)检查含有单一富鸟嘌呤寡核苷酸序列基序的核酸纳米支架，以及4)桥反转的亚甲基苯胺和苯肼等结构对的共结晶。核磁共振谱是化学家可以用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究不可或缺的一部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor J. Thomas Ippoliti and colleagues Bartholomew Dahl, Thomas C. Marsh and William H. Ojala from the University of St. Thomas will acquire a 400 MHz nuclear magnetic resonance (NMR) spectrometer with an autosampler unit. The instrument will be used to support research activities such as: 1) design and synthesis of oxazolidinone antimicrobial agents, photochromic naphthopyrans and biodegradable polylactides capable of adhering to metal stents, 2) exploration of use of a tethering lactone unit in the design and synthesis of biaryl molecular switches, 3) examination of nucleic acid nanoscaffolds containing a single guanine-rich oligonucleotide sequence motif, and 4) co-crystallization of isostructural pairs of "bridge-flipped" benzylideneanilines and phenylhydrazones.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.