MRI-R2: Development of an Instrument for Information Science and Computing in Neuroscience

提案#：09-59985PI(S)：阿祖阿迪，马雷克；巴雷托，阿曼多B.；盖拉德，威廉；贾亚卡尔，普拉萨纳；机构：佛罗里达国际大学标题：MRI-R2/Dev：神经科学中的信息科学和计算仪器这个项目开发了一个信息处理和计算仪器，能够对大脑进行连贯研究，涉及5-D大脑处理平台的新概念，同时解决了找到最佳方式组合五个维度以提供完整的大脑动力学图像的挑战。这种统一的方法将计算机工程、计算机科学、电气工程和生物工程领域结合在一起，创建了一种仪器，用于精确测量和可视化五个维度上的重要信息和结果，其中三个维度来自空间数据、时间和作为第五维度的成像模式。完成这一使命需要先进的设计、硬件-软件集成机制和新颖的接口，将相互竞争、有时甚至是不同的技术引入一个统一的大脑研究平台。这一新仪器结合了多站点数据库、模式集成和计算、可视化和操作支持单元，预计将带来：-对正常状态和特定病理条件下的大脑结构、功能相关性和动力学的新见解，-大大改进大脑活动模式的映射，-整合多模式技术，以增强其能力，同时巩固高空间分辨率和高时间分辨率，-数据库设计和管理，增加快速用户交互和可视化机制，以应对管理复杂的时空数据集、提出复杂的查询和建立有效的数据表示和可视化方法的挑战，以及-解决因使用不同的记录方式和不同的软件平台而面临繁重的计算要求和兼容性问题的那些范例。该项目旨在共同克服在确定影响大脑功能组织及其潜在病理的不同因素方面的主要障碍。例如，它深入研究了癫痫发作，当它沿着特定的纤维束移动时，可以随着时间的推移绘制地图，这可能有助于更好地识别特定的治疗区域，从而在手术期间保护大脑的重要功能部分，从而可能导致更好和更安全的结果。广泛影响：促进支持跨学科倡议、联合协作和计划的环境，该仪器建立了一个研究平台，使学术机构和医院能够根据系统管理的标准化协议调查多地点合作研究，并将协议标准化到共同评估和测量的数据库。该项目扩展了多学科努力的广度和深度，包括新的范例和发现。此外，该项目还促进了少数民族服务大学许多学生的教育、研究和培训。

"This award is funded under the American Recovery and Reinvestment Act of 2009(Public Law 111-5)."Proposal #: 09-59985PI(s): Adjouadi, Malek; Barreto, Armando B.; Gaillard,William; Jayakar,Prasanna; Rishe, Naphtali D.Institution: Florida International University Title: MRI-R2/Dev: Instrument for Information Science and Computing in NeuroscienceThis project, developing an instrument for information processing and computing that enables cohesive study of the brain, involves the new concept of a 5-D brain processing platform while addressing the challenge of finding the best way to put together five dimensions to provide a complete picture of brain dynamics. This unified approach brings together fields of Computer Engineering, Computer Science, Electrical Engineering, and Bioengineering to create an instrument for precisely measuring and visualizing significant information and results across the five dimensions, three from spatial data, time, and an imaging modality that serves as the fifth dimension. Accomplishing this mission involves advanced designs, hardware-software integration mechanisms, and novel interfaces that bring competing, and sometimes diverging, technologies into a unified brain research platform. Combining a Multi-site Data Repository, Modality Integration and Computational, Visualization, and Operation Support Units, this new instrument is expected to bring:- New insights into brain structure, functional correlations and dynamics, both in its normal state and under specific pathological conditions,- Far improved mapping of patterns of brain activity,- Integration of multimodal technologies in order to augment their capabilities with new insights while consolidating high spatial resolution with high temporal resolution,- Database design and management augmented with mechanisms for fast user interaction and visualization to meet the challenge of managing complex spatio-temporal datasets, posing complex queries, and establishing effective methods for data representation and visualization, and- Resolution of those paradigms that confront heavy computational requirements and compatibility problems that arise from the use of different recording modalities and diverse software platforms.The project aims to collectively overcome the primary barriers in identifying the different factors that influence the functional organization of the brain and its underlying pathology. As an example, it delves in the epileptic seizure that can be mapped over time as it moves along specific fiber tracts that may enable better identification of specific areas of treatment and consequently protect functionally important parts of the brain during surgery that may lead to better and safer outcomes.Broader Impacts: Fostering an environment that supports cross disciplinary initiatives, joint collaboration and programs, the instrument establishes a research platform that enables academic institutions and hospitals to investigate multi-site collaborative studies in accordance to systematically administered standardize protocols to a database of common assessments and measures. The project extends the breadth and depth of multidisciplinary efforts including new paradigms and findings. Moreover, the project advances the education, research, and training of many students in a minority serving university.