RUI:Directed Molecular Architectural Assembly via Dynamic Covalent Chemistry

美国国家科学基金会的大分子、超分子和纳米化学（MSN）项目支持霍利奥克山学院的达伦汉密尔顿教授关于开发和利用一种新方法来控制分子结构组装的工作。这项研究建立在经典的共轭加成化学的可行性，建立在可逆条件下，复杂的整体结构的碳框架。特别是，通过这种方法，拓扑结构复杂的有机分子轮烷和链烷的形成得到了促进，为具有潜在成像和传感性能的材料开辟了一条直接的途径。在该奖项的支持下，只有本科生的女子学院Mount霍利奥克的学生从事涵盖有机合成、结构分析和新材料性能研究的项目。一个溢价是放在建立简洁，廉价，模块化的方法，广泛的普遍适用性，以准备材料的当代问题，如传感和成像。对美国在这些领域的竞争力的贡献来自于该奖项支持下开展的具体研究，以及在合成和材料化学新兴领域接受培训的新一代本科生的准备。与当地高中教师的合作得到了支持，目的是将研究的说明性组成部分引入实验室教学。

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program at the National Science Foundation supports the work of Professor Darren Hamilton at Mount Holyoke College concerning the development and utilization of a new approach for the thermodynamically controlled assembly of molecular architectures. This research builds upon the viability of classic conjugate addition chemistry to establish, under reversible conditions, carbon frameworks of elaborate overall structure. In particular, the formation of topologically complex organic molecules-rotaxanes and catenanes-is facilitated via this approach, opening a straightforward route to materials with potentially valuable imaging and sensing properties.With support from this award students at Mount Holyoke, an undergraduate only women's college, work on projects that span organic synthesis, structural analysis, and investigations of the properties of new materials. A premium is placed on establishing concise, inexpensive, modular methods of broad general applicability to the preparation of materials for contemporary problems such as sensing and imaging. Contributions to US competitiveness in these fields is derived from both the specific research undertaken with support from this award, and from the preparation of new generations of undergraduates trained in emerging areas of synthetic and materials chemistry. Collaborations with local high school teachers are supported with the intention of drawing illustrative components of the research into laboratory teaching.