Natural Product Synthesis: A Context for the Study of Molecular Structure and Reactivity

在这个项目中，新泽西州立大学罗格斯大学化学和化学生物学系的劳伦斯·J·威廉姆斯教授，由化学系化学合成计划资助，旨在建立对不对称分子的结构和反应性的深刻理解，并显著扩展不对称分子在化学合成中的战略应用。作为该项目的一部分，将以富含对映体的形式合成由于稳定构象形成而不对称的化合物。不对称物种缺乏典型的立体起源中心或手性轴，很少被用作关键的战略要素。将为结构、机械和方法学研究准备合适的支架，并将对其进行立体选择性转化的能力进行评估，以提供结构复杂的自然产品供进一步研究。更广泛的影响包括在多样化和一体化的学习环境中培训本科生、研究生和博士后学生，这种学习环境鼓励知识和经验分享，并在更大的新泽西州化学界建立联系和合作。该项目可能会促进合成产品的制备技术。无论是化学品、试剂、催化剂、中间体、治疗剂、聚合物，还是分子工具、探针、材料或机器，合成产品的用途跨越了科学和工程，并渗透到现代世界。许多被归类为有机化学的知识直接或间接地来自于旨在合成具有挑战性的分子的研究，而复杂分子的合成仍然是促进我们对分子结构和反应性的理解的最有效的渠道。

In this project, funded by the Chemical Synthesis Program of the Chemistry Division, Professor Lawrence J. Williams of the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey aims to establish a deep understanding of the structure and reactivity of dissymmetric molecules and to extend significantly the strategic application of dissymmetric molecules in chemical synthesis. As part of this project, compounds that are dissymmetric due to stable conformer formation will be synthesized in enantioenriched form. Dissymmetric species lack the archetypal stereogenic center or axis of chirality and have been used as key strategic elements only very rarely. Suitable scaffolds will be prepared for structural, mechanistic, and methodology studies, and will be evaluated for their ability to undergo stereoselective transformations to give structurally complex natural products of value for further study. The broader impacts involves training undergraduate, graduate, and postdoctoral students in a diverse and integrated learning environment that encourages knowledge and experience sharing and builds ties and collaborations in the greater New Jersey chemistry community.This project could advance the knowhow to prepare synthetic products. Be they chemicals, reagents, catalysts, intermediates, therapeutics, polymers, or molecular tools, probes, materials, or machines, the uses of synthetic products span science and engineering and permeate the modern world. Much of the knowledge categorized as organic chemistry was extracted, either directly or indirectly, from studies aimed at the synthesis of challenging molecules and complex molecule synthesis continues to be the most effective conduit for advancing our understanding of molecular structure and reactivity.