SBIR Phase I: Scale-up Manufacturing of Nitric Oxide Nanotechnology for Healthcare Infections

这个小企业创新研究（SBIR）第一阶段项目旨在开发一种大规模生产一氧化氮释放二氧化硅纳米颗粒的工艺。主要的挑战是控制纳米颗粒的晶体尺寸，同时保持高水平的一氧化氮储存。本项目将对反应物加入速率、反应温度和混合速率等关键工艺参数进行研究。平衡成核和生长（BNG）模型将用于将过程数据转换为控制粒度的预测因子。该项目的更广泛/商业影响将是提供大容量一氧化氮释放二氧化硅纳米颗粒的潜力，用于预防和治疗传染病的产品。大量释放一氧化氮的二氧化硅纳米颗粒的可用性对于对抗不断上升的医院感染数量至关重要。然而，生产释放一氧化氮的二氧化硅纳米颗粒所需的放大技术还不具备。该项目有望为抗感染产品开发提供制造大量一氧化氮释放二氧化硅纳米颗粒的工艺。

This Small Business Innovation Research (SBIR) Phase I project aims to develop a scale-up manufacturing process of nitric oxide-releasing silica nanoparticles. The main challenge is controlling the nanoparticle crystal size while maintaining high levels of nitric oxide storage. In this project, critical process parameters including reactant addition rate, reaction temperature and mixing rate will be studied. The Balanced-Nucleation and Growth (BNG) Model will be utilized to transform process data into predictors of controlled particle size.The broader/commercial impact of this project will be the potential to provide large-volume nitric oxide-releasing silica nanoparticles for placement in products aimed at the prevention and treatment of infectious diseases. Availability of large-quantity nitric oxide-releasing silica nanoparticles is important to combat the rising number of nosocomial infections. However, the necessary scale-up technology to manufacture nitric oxide-releasing silica nanoparticles is not available. This project is expected to provide the processes to manufacture large quantities of nitric oxide-releasing silica nanoparticles for anti-infective product development.