Conference - FASEB meeting on Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay to be held July 11-16, 2010 in Carefree, AZ

智力优势：关于基因表达的转录后控制：信使核糖核酸衰退的机制？将于2010年7月11日至16日在亚利桑那州的无忧无虑举行。信使RNA周转是基因表达的关键调节因子。MRNA的稳定性在很大程度上决定了它的稳定积累，并可以受到细胞内和细胞外环境因素的调节，以提供对调节信号的快速反应机制。程序性稳定或不稳定的mRNAs可分别增强或抑制基因表达。此外，多条监测途径利用mRNA周转来维持mRNA的质量，并确保只有经过适当处理的转录本才能离开细胞核，并被翻译机构用作底物。此外，非编码RNA和RNA干扰最近引起了生命科学各个领域的极大兴趣，因为它们依赖于选择性的mRNA周转来实现其对基因沉默的生物学影响。这次会议已经发展成为一次独特的会议，将真核生物、考古细菌和原核生物系统中领先的信使核糖核酸周转专家聚集在一个舞台上，并为信使信使周转这一广泛学科的研究人员提供了一个互动、交流思想和催生未来研究新领域的机会。我们预计，这次会议将为老牌研究人员和受训人员提供对这一令人兴奋的领域当前和未来方向的出色概述，因为他们有助于推动该领域的下一步发展。更广泛的影响：会议的更广泛影响包括促进初级调查人员发展的机会。会议的形式旨在促进所有参与者之间的最大科学互动，并确保学生和博士后同事能够与信使核糖核酸周转领域的领导者会面并讨论他们的研究和未来计划。所有参与者都有机会展示他们的研究海报。此外，每个平台会议将包含至少一位初级科学家的口头演讲，这些演讲是从提交的海报摘要中挑选出来的，以便为年轻科学家提供最大的曝光率。

Intellectual merit: The FASEB Conference on ?Posttranscriptional control of gene expression: mechanisms of mRNA decay? will be held in Carefree, AZ on July 11-16, 2010. Messenger RNA turnover is a critical regulator of gene expression. The stability of an mRNA significantly dictates its steady-state accumulation and can be modulated by both intracellular and extracellular environmental factors to provide a rapid response mechanism to regulatory signals. Programmed stability or instability of mRNAs can enhance or repress gene expression, respectively. Moreover, multiple surveillance pathways utilize mRNA turnover to maintain mRNA quality and ensure only properly processed transcripts exit the nucleus and are utilized as substrates by the translation machinery. In addition, noncoding RNAs and RNA interference have recently attracting considerable interest from all areas of the life sciences, since they rely on selective mRNA turnover for their biological consequence on gene silencing. This meeting has developed into a unique conference that brings together the leading mRNA turnover experts in eukaryotic, archaebacteria and prokaryotic systems into one arena and provides an opportunity for researchers in the broad discipline of mRNA turnover to interact, exchange ideas and spawn new areas of future research. We anticipate this conference will provide an outstanding overview of the current and future direction of this exciting field for established investigators and trainees as they help propel the field to the next level of its development.Broader impacts: The broader impact of the conference includes the opportunity to foster the development of junior investigators. The format of the conference is designed to promote maximal scientific interactions among all the participants and ensure students and postdoctoral associates will be able to meet and discuss their research and future plans with leaders in the mRNA turnover field. All participants have an opportunity to present posters on their research. In addition, each platform session will contain at least one oral presentation by junior scientists selected from the submitted poster abstracts to provide maximal exposure for young scientists.