Partial Support for U.S. Participation in Workshop "Unlocking and Developing Collections for Genomic Research"

摘要DNA测序技术的巨大进步使得从灭绝的生物和濒临灭绝的物种中产生和分析大量的基因组信息成为可能，从而为使用基因组序列来研究灭绝过程提供了一个难得的机会。最近的研究结果结合了基因组测序技术的进步和提取足够数量的可用DNA的方法，正在扩大古基因组学研究对古生物学领域的贡献。从濒临灭绝的动植物身上获取遗传信息和回顾性分析已灭绝动物遗传属性的能力，提供了一种新的信息来源，适用于评估不断变化的环境的影响，包括新出现的疾病和气候变化对数万年来物种持续存在或减少的影响。DNA测序技术的发展对古基因组学和灭绝基因组学的发展至关重要，因此对这些研究有用样本的收集至关重要。冷冻标本的收藏和博物馆藏品将为研究在不断变化的环境中随时间发生的变化提供重要的样本。为了给包括冷冻生物材料和DNA标本在内的博物馆藏品的利用提供一个视角，召开科学研讨会提供了一个讨论保存方法和发展合作研究的论坛。这一提议促进了这一新兴领域的六名美国专家参加一个名为？解锁和开发基因组研究的馆藏？会议将于2010年6月11日在伦敦自然历史博物馆举行，前一天还将举行林奈学会会议，题为？给红色和死亡排序？他们的出席对于美国科学家在这一新兴研究领域保持竞争优势非常重要。

Partial Support for U.S. Participation in Workshop "Unlocking andDeveloping Collections for Genomic Research"Oliver RyderZoological Society of San DiegoAbstractThe tremendous advances being made in DNA sequencing technology now make it possible to generate and analyze extensive genomic information from extinct organisms and species on the brink of extinction, thereby providing a remarkable opportunity to use genomic sequences to study the extinction process. The results of recent studies that incorporate advancements in genome sequencing technology and methods to extract sufficient amounts of serviceable DNA are expanding the contributions of paleogenomic studies to the field of paleontology. The ability and to capture genetic information from animals and plants on the brink of extinction and to retrospectively analyze genetic attributes of extinct animals provides a new source of information applicable to evaluating the impacts of changing environments, including the impacts of newly emerging diseases and climate alterations on the persistence or decline of species over tens of thousands of years. The technological developments in DNA sequencing technology that are crucial to the developing field of paleogenomics and the genomics of extinction focus attention on the crucial importance of collections of samples useful for these studies. Collections of frozen specimens and Museum collections will provide vital samples to study changes taking place over time in changing environments. In order to provide a perspective for the utilization of museum collections, including collections of frozen biomaterials and DNA specimens, convening of scientific workshops provides a forum for discussion of preservation methods and development of collaborative studies. This proposal facilitates the participation of six U.S.-based scientists who are experts in this newly-emerging field, to participate in a workshop entitled ?Unlocking and Developing Collections for Genomic Research? to be held on June 11, 2010, at the Natural History Museum in London, and an accompanying Linnaean Society Meeting the preceding day entitled ?Sequencing the Red and the Dead?. Their attendance at this meeting is important for U.S. scientists to maintain a competitive advantage in this newly emerging field of investigation.