GOALI: Implementation of Biodegradable Material Models in ANSYS

1067750 moore由于缺乏合适的建模工具，许多可生物降解医疗植入物的设计优化受到阻碍。在这些应用中，植入物？S的几何形状和它所承受的机械载荷可能相当复杂。这导致植入物内部的应变场在空间上发生变化，这可能导致某些部分比其他部分退化得更快。不幸的是，对空间依赖的应变加速退化进行建模的能力还没有得到很好的发展，而且在医疗器械行业常用的有限元建模（FEM）工具中完全没有。有限元法涉及使用计算技术来求解复杂几何结构的应力。摩尔实验室已经开始为菌株加速生物降解过程构建材料描述模型。虽然最初成功地描述了一般特征，但这些模型的进一步应用需要广泛的模型细化。德克萨斯a&m大学和ANSYS公司之间的这一GOALI提案旨在为模型开发提供这些后续步骤。具体而言，目标是：1。通过对几种聚合物在生理循环负荷下的生物降解行为的广泛测量，发展初始的生物可降解材料模型。通过将这些模型部署到ANSYS力学分析有限元软件包中，确保这些模型的适用性。这种建模技术的可用性将对医疗植入物设计人员有很大的好处，他们希望有一个可预测的结构破坏时间。行业合作伙伴ANSYS公司的参与为该项目带来了巨大的价值。他们的建模软件被大量医疗设备制造商所使用，所有这些制造商都在努力开发可生物降解的植入物。这些模型的发展将使医疗设备设计师以外的社区受益。在生物医学界，仍有许多人努力设计功能性组织工程结构，以取代患病的身体部位。在许多情况下，这些结构是由可生物降解的材料制成的，由嵌入或周围细胞的作用代替。本项目中开发的建模技术将适用于这些情况，并添加了表示单元动作的参数。在生物医学界之外，还有许多其他种类的材料经历应变加速降解的情况，包括建筑环境（人造结构），汽车和航空航天部门。这些新模型的商业可用性将使所有这些领域受益，并使更广泛的受众了解这些新材料模型的潜在广泛益处。行业合作伙伴ANSYS， Inc.的参与增加了重要的价值，使这些模型可用于广泛的社区，并宣传其潜在的好处。博士后和本科研究人员的培训方面将有利于在工程领域代表性不足的群体（女性）。

1067750MooreDesign optimization of many biodegradable medical implants is hampered by a lack of appropriate modeling tools. In these applications, the implant?s geometry and the mechanical loads to which it is subjected may be quite complex. This leads to spatially varying strain fields within the implant, which can cause certain parts to degrade faster than others. Unfortunately, the ability to model spatially dependent strain accelerated degradation is not well developed, and completely absent in the finite element modeling (FEM) tools commonly used in the medical device industry. FEM involves using computational techniques to solve for stresses in structures with complex geometries.The Moore laboratory has begun constructing material description models for strain accelerated biodegradation processes. While initially successful in describing general characteristics, the further application of these models requires extensive model refinement. This GOALI proposal between Texas A&M University and ANSYS, Inc. aims to provide these next steps in model development. Specifically, the objectives are:1. Evolve the initial biodegradable material models through an extensive set of measurements of the biodegradation behavior of several polymers subjected to physiologic cyclic loading.2. Ensure the applicability of these models by deploying them in the ANSYS Mechanical Analysis FEM software package.The availability of such modeling techniques will be of great benefit to medical implant designers who desire a predictable time to structural breakdown. There is significant value brought to the project by the participation of the industry partner, ANSYS, Inc. Their modeling software is being used by a large number of medical device manufacturers, all of whom are trying to develop biodegradable implants.The development of these models will benefit communities other than medical device designers. Still within the biomedical community, there are many efforts to design functional tissue engineered constructs that can replace diseased body parts. In many cases, these constructs are made from biodegradable materials that are replaced by the actions of embedded or surrounding cells. The modeling techniques developed in this project will be applicable to these situations, with the addition of parameters that represent cell actions. Outside the biomedical community, there are many situations in which other sorts of materials experience strain accelerated degradation, including the built environment (man-made structures), automotive, and aerospace sectors. The commercial availability of these new models will benefit all of these fields, and educate a broader audience on the potential wide-ranging benefits of these new material models. The participation of the industry partner, ANSYS, Inc. adds significant value in making these models available to a broad community and publicizing their potential benefits. The post-doctoral and undergraduate researcher training aspects will benefit groups that are under-represented in engineering (females).