Exploring Transition Metals in Carbohydrate Synthesis

通过这一奖项，化学合成项目正在支持爱荷华大学化学系阮海恩教授的工作。阮教授将探索通过过渡金属催化有效制备α-构型糖基脲和1，2-顺式-2-氨基糖的新方法。这些方法的成功开发将为快速组装许多复杂的碳水化合物靶标提供新的有效方法，包括潜在的基于糖共轭的肿瘤相关抗原、氨基糖苷类抗生素和抗结核药物。该项目的具体目标包括糖基尿素类抗生素Cinodine和糖基磷脂酰肌醇(GPI)锚定的伪寡糖。拟议项目的更广泛影响将包括培训本科生和研究生，继续建立一个将过渡金属催化与碳水化合物合成相结合的项目。通过这种方式，该项目将为这些学生提供多学科培训，包括那些在科学界历史上代表性不足的学生。这项工作还具有重要的潜在的更广泛的科学影响，因为这项工作有望为糖科学界提供立体控制的糖基化和糖共轭的新的和可推广的方法。

With this award, the Chemical Synthesis program is supporting the work of Professor Hien Nguyen of the Department of Chemistry at the University of Iowa. Professor Nguyen will explore the development of new methods for the effective preparation of alpha-configured glycosyl ureas and 1,2-cis-2-aminosugars via transition metal catalysis. Successful development of these methods will provide new and efficient approaches for the rapid assembly of a number of complex carbohydrate targets, including potentially glycoconjugate-based tumor-associated antigens, aminoglycoside antibiotics, and anti-tubercular drugs. Specific targets for this project include the glycosyl urea antibiotic cinodine, and glycosylphosphatidyl inositide (GPI) anchor pseudo-oligosaccharides. The broader impacts of the proposed project will involve training both undergraduate students and graduate students, in continuing to build a program that merges transition-metal-based catalysis with carbohydrate synthesis. In this way, the project will provide multidisciplinary training for these students, including those from groups historically underrepresented in the sciences. There are also important potential scientific broader impacts, as this work is expected to provide new and generalizable methods for stereocontrolled glycosylation and glycoconjugation to the glycoscience community.