Multidimensional Incoherent Spectroscopy for Measuring Condensed-Phase Dynamics

在化学系化学测量和成像项目的支持下，南卡罗来纳州大学的Mark贝格教授和他的团队正在开发和应用新方法来评估异质材料中化学过程（包括肽构象动力学）的速率。 传统的“一维”光谱方法使用单个激发源并在单个时间段内测量速率。 贝格教授正在开发多维方法，该方法使用多个激励源并在多个时期内测量速率。 通过使用三个激发脉冲，将测量构象变化的分布和速率。 多维方法也正在扩大到包括可变偏振的光脉冲，从而测量本体聚合物内的局部粘度分布。动力学测量在化学、生物学、物理学和工程学中都有应用。 该计划中开发的动力学的全新方法将为所有这些领域提供新的工具。 高级光谱学的培训将在南卡罗来纳州大学进行，该大学在地理上服务不足，并且有大量来自代表性不足群体的学生。 此外，贝格教授正在与斯佩尔曼学院的Peter Chen教授合作，使该项目的技术发展适应本科生的研究环境。

With support from the Chemical Measurement and Imaging program in the Division of Chemistry, Prof. Mark Berg and his group at the University of South Carolina are developing and applying new methods to assess the rates of chemical processes (including peptide conformational dynamics) in heterogeneous materials. Traditional "one-dimensional" spectroscopic methods use a single excitation source and measure rates over a single time period. Prof. Berg is developing multidimensional methods that use more than one excitation source and measure rates over multiple periods. By using three excitation pulses, both the distribution and rates of conformational change will be measured. Multidimensional methods are also being broadened to include light pulses of variable polarization and thereby measure the distribution of local viscosities within bulk polymers. Kinetic measurements are used throughout chemistry, biology, physics and engineering. The fundamentally new approaches to kinetics developed in this program will provide new tools to all these areas. Training in advanced spectroscopy will be done at the University of South Carolina, which is both geographically underserved and has a large population of students from underrepresented groups. In addition, Prof. Berg is collaborating with Prof. Peter Chen of Spelman College, an HBCU for women, to adapt the technological development from this project to an undergraduate research environment.