International Collaboration in Chemistry: Single-Molecule Imaging, Dynamics,and Electronics at Multivalent Host-Guest Surfaces

美国研究人员与国外同行（ICC）项目之间的化学国际合作重点是开发复杂的超分子组装和测量，以推进化学和纳米科学领域的最新技术水平。 具有短链的高度有序的环糊精单分子膜组装在金属基底上。这些组件用于使用高分辨率扫描隧道显微镜（STM）的研究，以了解前所未有的细节疏水客体分子的结合。单（超）分子研究使电子和化学调查的单客体结合，以及直接表征多价结合和活性客体分子的图案化和耦合。 加州大学洛杉矶分校的韦斯小组得到了美国国家科学基金会化学部大分子、超分子和纳米化学项目的支持，国际科学与工程办公室也提供了资助。 特文特大学的Huskens小组得到了荷兰科学研究组织（NWO）的支持，NWO是一个合作的国际资助机构。分子界面识别过程是许多重要的技术和生物过程和现象的核心。 这项工作旨在更深入地了解分子界面识别，这可能与太阳能转换和电子传感器和生物医学应用等不同领域有关。 此外，已知多价性是生物系统中活性的关键组分，特别是对于细胞膜识别。环糊精单分子膜作为解决此类膜的多价性问题的优秀模型系统发挥作用。 该项目的强互动和多样化的研究环境为教学，培训和学习提供了一个环境。 学生对合作实验室进行合作工作和培训的扩展访问为学生提供了非常宝贵的国际经验。

This International Collaboration in Chemistry between US Investigators and their Counterparts Abroad (ICC) project focuses on developing sophisticated supramolecular assemblies and measurements to advance the state of the art in this area of chemistry and nanoscience. Highly ordered cyclodextrin monolayers with short tethers are assembled on metal substrates. These assemblies are used for studies using high-resolution scanning tunneling microscopy (STM) to understand binding of hydrophobic guest molecules with unprecedented detail. Single (supra)molecular studies enable both electronic and chemical investigations of single-guest binding, as well as direct characterization of multivalent binding and active guest molecule patterning and coupling. The Weiss group at UCLA is supported by the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Chemistry Division, with contribution from the Office of International Science and Engineering. The Huskens group at the University of Twente is supported by the Netherlands Organization for Scientific Research (NWO), the partnering international funding agency.The process of molecular interfacial recognition is central to many important technological and biological processes and phenomena. This work aims to gain a deeper understanding of molecular interfacial recognition which might be relevant for areas as diverse as solar energy conversion and electronics to sensors and biomedical applications. In addition, multivalency is known to be a critical component of activity in biological systems, in particular for cell membrane recognition. Cyclodextrin monolayers function as excellent model systems to address multivalency issues at such membranes. The strong interactive and diverse research environments of this project provides a setting for teaching, training and learning. The extended visits of students to partner laboratories for collaborative work and training provide students with highly valuable international experience.