Golgi-associated protein scaffolds regulating receptor targeting and hormone secretion (A13)

A13研究了高尔基体相关支架对脂肪和胰岛β细胞分泌激素的作用。小的反式高尔基体GTP酶ARFRP1及其下游支架蛋白影响(I)肠细胞中的脂滴蛋白组成，(Ii)介导胰岛素和转铁蛋白受体的内吞循环，以及(Iii)脂联素和胰岛素的分泌所必需的。未来的目标是阐明支架蛋白GOPC的功能，GOPC是一种最近发现的ARFRP1相互作用蛋白，也与逆转录体亚单位VPS35相互作用。A13将检验ARFRP1和GOPC共同调节逆转录病毒介导的内体循环过程的假设。

A13 examines the role of Golgi-associated scaffolds on hormone secretion by fat and pancreatic beta-cells. The small trans-Golgi residing GTPase ARFRP1 and its downstream scaffolding proteins affect (i) lipid droplet protein composition in intestinal cells, (ii) mediate endocytotic recycling of the insulin and transferrin receptors and (iii) are required for the secretion of adiponectin and insulin. The future aim is to clarify the function of the scaffolding protein GOPC, a recently identified ARFRP1 interacting protein that also interacts with the retromer subunit VPS35. A13 will test the hypothesis that ARFRP1 and GOPC together regulate retromer-mediated endosomal recycling processes.