GRK 1830: Complex Membrane Proteins in Cellular Development and Disease

膜蛋白的功能障碍和蛋白区划可以严重损害细胞和器官的正常功能，并与免疫介导性疾病、耳聋、囊性纤维化、癌症、心血管功能障碍和阿尔茨海默氏症等有害疾病有关。此外，许多膜蛋白活性的改变会对动植物细胞的发育和细胞适应过程产生重大影响。凯泽斯劳滕大学生物系和萨尔兰大学医学和生物科学学院发表的关于发育和疾病中的复合膜蛋白的IRTG研究了选定的膜转运蛋白、蛋白质靶向和跨生物膜的转位、蛋白质折叠以及膜蛋白质在发育过程和疾病中的作用。IRTG涵盖了两所德国大学的11名知名资深学者和3名年轻学者，以及来自加拿大艾伯塔大学埃德蒙顿分校医学和牙科学院的13名备受瞩目的研究人员，其中包括5名女性PI作为重要榜样。我们的科学使命是(I)产生关于膜蛋白丰度和活性控制的基本信息，(Ii)了解它们的生化和功能性质，以及(Iii)将感兴趣的蛋白质(S)置于正常和病理条件下的生理环境中。为此，IRTG提供了一系列无与伦比的强大实验模型系统的选择，如各种原代人类细胞类型、小鼠模型、酵母或拟南芥，并提供了广泛的复杂实验方法。IRTG为膜生物学及相关领域的研究生创造了一个出色的培训环境。博士指导委员会由两名当地成员和一名来自埃德蒙顿的教授组成，促进协调研究/教育并确保高标准的国际标准。所有受训人员必须在伙伴机构完成为期几个月的研究，参加国际讲习班进一步便利他们融入科学界。我们即将建立一个联合学位项目，通过该项目，我们的毕业生可以获得双方合作授予的博士学位。定期邀请来自国际和国内主要研究中心的科学家参加讲座/研讨会和实践培训课程。由学员独立组织的活动和选定的软技能模块完成了我们毕业生在学术界、科研院所和行业担任领导职位的资格。

The dysfunction of membrane proteins and protein compartmentalization can seriously compromise the normal functioning of cells and organs and has been implicated in detrimental diseases such as immune mediated diseases, deafness, cystic fibrosis, cancer, cardiovascular dysfunction and Alzheimer's. Moreover, altered activity of many membrane proteins causes dramatic effects on developmental and cellular adaptation processes in animal and plant cells. The IRTG on Complex Membrane Proteins in Development and Disease forwarded by the Faculty of Biology of the University of Kaiserslautern and the Faculties of Medicine and Biosciences of the Saarland University investigates selected membrane transporters, protein targeting and translocation across biological membranes, protein folding and the role of membrane proteins in developmental processes and diseases. The IRTG covers eleven renowned senior and thee young academics of two German universities and thirteen highly profiled researchers from the Faculty of Medicine and Dentistry at the University of Alberta at Edmonton (Canada), including five female PIs as important role models. Our scientific mission is to (i) generate fundamental information about the control of abundance and activity of membrane proteins, (ii) understand their biochemical and functional properties and (iii) set the protein(s) of interest into the physiological context under normal and pathological conditions. For this purpose, the IRTG offers access to an inimitable selection of powerful experimental model systems like various primary human cell types, mouse models, yeast or Arabidopsis and provides a broad array of sophisticated experimental approaches. The IRTG has created an outstanding training environment for graduate students in the area of membrane biology and related fields. PhD guidance committees comprise two local members and one professor from Edmonton, facilitating coordinated research/education and ensuring high international standards. All trainees have to complete a research stay of several months at the partner institution and participation in international workshops further facilitates their integration into the scientific community. We are close to establishing a joint degree programme, through which our graduates can earn a PhD degree granted cooperatively by both sides. Scientists from major international and national research centers are regularly invited for lectures/seminars and practical training courses. Events independently organized by the trainees and selected soft skill modules complete the qualification of our graduates for leading positions in academia, research institutes and industry.