Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo

膝关节置换手术是终末期骨性关节炎的既定治疗方法。这项建议解决了与膝关节置换手术相关的最基本的问题之一：为什么全膝关节置换失败？高保真的、针对患者的步行计算机模拟可以帮助回答这个问题，这样做可以改善当前膝关节植入物设计的功能性能和寿命。对人体运动的逼真计算机模拟还可以通过患者康复在医疗保健中发挥关键作用；通过为精英运动员开发个性化训练计划在体育领域发挥关键作用；通过创建视频游戏和动画电影在娱乐领域发挥关键作用。

Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity of current knee implant designs. Realistic computer simulations of human movement also can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.