CAREER: Integrated Research and Education on Microscale Ferrohydrodynamic Manipulation

目的：该项目的目标是将理论、数值和实验研究相结合，研究铁磁流体力学及其在微观尺度上操纵非磁性物体(如分子、粒子、细胞和液滴)的应用。智力优势：智力优势是一项融合了胶体化学、磁学和流体力学的多学科研究计划，将基础建模和分析与面向应用的实验相结合。它导致了可测试的理论预测和对分子和粒子的铁流体动力学操纵的物理理解，使其能够在微流控设备中得到实际和有用的应用。一种涉及磁流体的新方法将被用来为分子和细胞提供一个磁性均匀的环境，这些分子和细胞可以通过外部磁场以可控的速度和方向传输。通过这项研究，将能够实现磁流体中分子的快速混合和对细胞的高效操纵。广泛的影响：更广泛的影响是：(1)该计划不仅将促进对耦合纳米尺度磁现象和流体动力学的基本了解，而且将产生一个变革性的磁操作平台，可适用于微流体生物传感器、诊断芯片、血液净化设备和单细胞研究等广泛领域；(2)该计划将把研究与本科生和研究生的讲座和实验室作业相结合，增加少数族裔和女性学生？参与科学和工程，并通过暑期研究所将科学概念的意识带给使用磁流体的K-12学生。供K-12教师使用。

Objective: The objective of this program is to combine theoretical, numerical and experimental studies to investigate ferrofluid hydrodynamics and its applications in manipulating non-magnetic objects (such as molecules, particles, cells and droplets) at the micro-scale for lab-on-a-chip applications.Intellectual Merit: The intellectual merit is a multi-disciplinary research program that incorporates colloidal chemistry, magnetism and fluid mechanics, combining fundamental modeling and analysis with application-oriented experiments. It results in testable theoretical predictions and a physical understanding of ferrohydrodynamic manipulation of molecules and particles that enables practical and useful applications in microfluidic devices. A novel approach involving ferrofluids will be used to provide a magnetically uniform environment for molecules and cells, which can be transported with controlled speed and direction via external magnetic fields. Fast mixing of molecules and efficient manipulation of cells within ferrofluids will be enabled through this research.Broader Impact: The broader impacts are: (1) this program will not only advance the fundamental understanding of coupled nano-scale magnetic phenomena and fluid dynamics, but also produce a transformative magnetic manipulation platform that is applicable to a broad range of areas such as microfluidic biosensors, diagnostic chips, blood cleansing devices, and single cell studies; (2) this program will integrate research with lectures and laboratory assignments for undergraduate and graduate students, increase minority and female students? participations in science and engineering, and bring awareness of scientific concepts to K-12 students using ferrofluids through a ?Summer Institute? for K-12 teachers.