Development, Application, and Mechanism of Enantioselective Hydroformylation

美国威斯康星大学麦迪逊分校的Clark R. Landis教授获得了化学催化项目的这一奖项，他将通过设计和合成新型有机膦化合物3,4-二氮磷烷，推动催化技术的发展。手性过渡金属配合物催化的高效、选择性和原子经济转化是一项具有成本效益和环境友好的手性药物、农用化学品和天然产物合成的关键技术。该项目解决了以下方面的智力挑战：(1)使用模块化和珠状合成技术创建具有不同功能基团的手性催化剂环境；(2)了解在氢甲酰化反应中如何控制对映选择性和活性；(3)通过将对映选择性氢甲酰化扩展到新的底物类别、反应条件，在实验室和工业工厂规模上由有机化学家实现对映选择性催化。以及在多步合成中加入对映选择性氢甲酰化。除了科学影响之外，这项工作还将通过开发高效、低浪费的工艺，以及通过培训本科生和研究生从事科学、技术和工程领域的职业，来支持美国化学和制药工业的竞争力。

With this award from the Chemical Catalysis Program, Professor Clark R. Landis from University of Wisconsin at Madison will advance the state-of-the-art of catalysis through the design and synthesis of novel organophosphine compounds, 3,4-diazaphospholanes. Efficient, selective, and atom economical transformations catalyzed by chiral transition metal complexes represent a critical technology for cost-effective and environmentally-benign synthesis of chiral pharmaceuticals, agrochemicals, and natural products. This project addresses the intellectual challenges of (1) creating chiral catalyst environments with diverse collections of functional groups using modular and bead-based syntheses (2) understanding how enantioselectivity and activity are controlled in hydroformylation reactions and (3) implementing enantioselective catalysis by organic chemists at both the bench and industrial plant scales through extension of enantioselective hydroformylation to new substrate classes, reaction conditions, and the incorporation of enantioselective hydroformylation into multistep syntheses.In addition to the scientific impact this work will support the competitiveness of U. S. chemical and pharmaceutical industries through the development of efficient, low-waste processes and through the training of undergraduate and graduate students for careers in science, technology, and engineering fields.