Probing Anaesthetic Effects with New Functional Imaging Paradigms

该项目寻求麻醉药对大脑功能和修复影响的新见解。麻醉用于小动物成像以固定动物，但在许多情况下，麻醉本身会影响所研究的神经生理参数。研究还表明，许多麻醉剂能促进小动物脑损伤后的恢复。该项目计划开发一种新的功能性脑成像技术，用于有意识的动物，以获得麻醉对脑功能和损伤恢复的影响的新见解。所获得的知识有望提高对麻醉作用的认识，指导未来在小动物成像中使用麻醉剂，以提高图像衍生研究数据的准确性，并有助于阐明麻醉剂如何在脑损伤中赋予神经保护作用。

This project seeks new insights into the effects of anaesthetics on brain function and repair. Anaesthesia is used in small-animal imaging to immobilise the animal, but in many cases the anaesthesia itself affects the neurophysiological parameters under study. It has also been shown that many anaesthetics enhance recovery after brain injury in small animals. This project plans to exploit a novel functional brain-imaging technique for conscious animals to gain new insights into the effects of anaesthetics on brain function and recovery from injury. The knowledge gained is expected to improve knowledge of anaesthetic action, guide future anaesthetic use in small animal imaging to improve the accuracy of image-derived research data, and help to clarify how anaesthetics confer neuroprotective effects in brain injury.