Temporal and spatial contrast phenomena in pain networks (A06)

我们将建立在新的功能磁共振成像（fMRI）脉冲序列来研究疼痛的空间和时间对比现象的网络特性。我们将进一步改进皮质-脊柱功能磁共振成像，并进行功能磁共振成像网络研究和行为调查，以测试脊柱对时间（偏移镇痛）和空间对比（热烤架错觉；TGI）现象的贡献。此外，我们将使用功能磁共振成像进一步研究PAG编码疼痛衍生信号的观察结果，以及该信号如何整合到其他伤害感知区域（如次级体感皮层和前脑岛）的网络中。

We will build upon novel functional MRI (fMRI) pulse sequences to study the network properties underlying spatial and temporal contrast phenomena in pain. We will further improve cortico-spinal fMRI and perform fMRI network studies and behavioral investigations to test for a spinal contribution to temporal (offset analgesia) and spatial contrast (thermal grill illusion; TGI) phenomena. In addition, we will use fMRI to further investigate the observation that the PAG codes a pain derivative signal and how this signal is integrated into the network of other nociceptive areas such as the secondary somatosensory cortex and the anterior insula.