MRI: Acquisition of a Wide Range Particle Spectrometer

该提案要求提供资金，以获得一个大范围粒子光谱仪（WPS），用于表征大范围（即，纳米到微米尺寸）的气溶胶颗粒。需要该装置来支持具有受试者特定气道模型的气雾剂吸入实验。PI使用ScanIP图像处理软件提取多达8代气道（含或不含口腔）的3D图像文件，然后通过熔融沉积成型3D快速成型机创建。模型可用于正常和患病的成人患者以及患病的儿科患者气道。然后将原型放置在PI的吸入气溶胶动力学实验室的测试室中。除WPS外，所有组件，包括振动孔式气溶胶发生器和冷凝气溶胶发生器，都可用于气流实验。可以控制潮气量和呼吸速率来模拟久坐和运动状态。通过用离子水冲洗肺模型的相关部分并测量沉积油滴中存在的尿氨酸量，获得区域沉积测量值。虽然提案中没有描述，但将开发从用于创建流过原型的相同3D图像文件创建的计算模型，以与实验结果进行比较。PI，Sinjae Hyun，博士（机械工程，NCSU，1998年）是美世大学的工程副教授和工程研究项目主任，自2003年以来一直在那里工作。2010年，他在美国环保署吸入剂量学研究实验室休假，以获得呼吸系统中吸入气雾剂运输和沉积实验的培训。他和一名本科生研究助理在2011年夏天继续接受培训。一封来自Chong S，Kim，PhD，EPA的强有力的支持信，他承诺合作和建议。

The proposal requests funds to acquire a Wide range Particle Spectrometer ( WPS) for characterizing a wide range (i.e., nano to micron sized ) aerosol particles. The device is needed to support aerosol inhalation experiments with subject specific airway model. The PI has used ScanIP image processing software to extract 3D images files of up to 8 airway generations with or without the oral cavity, which are then created by a fused deposition molding 3D rapid prototyping machine. Models are available for normal and diseased adult patients and for diseased pediatric patient airways. The prototypes are then placed in a testing chamber in the PI's Inhalation Aerosol Dynamics lab. With the exception of the WPS, all components, including a Vibrating Orifice Aerosol Generator and a Condensation Aerosol Generator, are available for the air flow experiments. Tidal volumes and breathing rates can be controlled to mimic sedentary and exercise states. Regional Deposition Measurements will be obtained by washing out pertinent sections of the lung models with ionized water and measuring the amount of uranine that was present in the deposited oil droplets. Though not described in the proposal, computational models created from the same 3D image files used to create the flow through prototypes would be developed for comparison with the experimental results. The PI, Sinjae Hyun, PhD (Mechanical Engineering, NCSU, 1998) is an Associate Prfoessor od Engineering and Director of the Engineering Research Program at Mercer University, where he has been since 2003. In 2010 he took a sabbatical leave at the US EPA Inhalation Dosimetry Study Lab to obtain training for inhalation aerosol transport and deposition experiments in the respiratory system. He and an undergraduate research assistant continued the training in the summer of 2011. A strong letter of support was included from Chong S, Kim, PhD, EPA, who promised collaboration and advice.