TUES Type 1: Incorporation of Research Skills into the Undergraduate Biochemistry Curriculum to Create Extraordinary Scientists for the Modern Research Environment

本项目建立了两个学期的生物化学实验系列课程，生物化学I和II，学生在课堂上进行研究项目，这些研究项目是校内教师研究项目的产物。学生们在每学期结束时展示他们的作业。该项目的一个独特之处是由行业代表和附近机构的教师组成的咨询委员会。该委员会帮助评审学生的演讲以及项目本身的设计和实施。每年约有130名学生将从该项目中受益。智力优势：严格的评估计划包括比较学生在以研究为中心的课程中获得的知识、技能和科学见解，以及学生参加更传统的标准实验模块为中心的课程。研究课题是当前和具有挑战性的，但适合学生。例子包括：二氢叶酸还原酶和吲哚-2-甘油磷酸合成酶的结构-功能关系，针对新靶点的激酶抑制剂的筛选，以及土壤酶学实验。更广泛的影响：如果这种方法取得成功，许多靠近适当工业中心和研究中心的城市大学都可以采用这种方法。该项目由生物科学理事会和本科教育司教育与人力资源理事会共同资助，作为支持本科生物学教育的愿景与变革的一部分。

This project is establishing a two semester series of biochemistry laboratory courses, Biochemistry I and II, in which students carry out class research projects that are an outgrowth of the research projects of on-campus faculty. Students present their work at the end of each semester. A unique feature of the project is an advisory board composed of industry representatives and faculty from nearby institutions. The board helps critique student presentations and the design and implementation of the project itself. Approximately 130 students/year will benefit from this project.Intellectual Merit: The rigorous evaluation plan includes comparison of the knowledge, skills, and scientific insights gained by students in the research centered courses to those gained by students taking the more traditional standard lab modules centered courses. The research topics are current and challenging but appropriate for the students. Examples include: structure-function relationships for dihydrofolate reductase and indole-2-glycerol phosphate synthase, screening of kinase inhibitors against new targets, and experiments in soil enzymology. Broader Impact: if successful this approach is one that could be adapted by many urban universities close to centers of appropriate industries and research centers.This project is being jointly funded by the Directorate for Biological Sciences and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts toward support of Vision and Change in Undergraduate Biology Education.