CAREER: Combining Nuclear Magnetic Resonance with Integrated Circuit Technology

职业生涯：结合核磁共振与集成电路技术孙楠（德克萨斯大学奥斯汀分校）智力优势。核磁共振（NMR）是原子核与射频磁场之间的共振相互作用。它在化学、生物学、物理学、医学和材料科学中有广泛的应用。尽管它的多功能性和巨大的贡献，现有的NMR系统具有有限的灵敏度，低吞吐量和长的实验时间的限制。此外，它们体积大、重且昂贵。这些缺点限制了它们的能力和可及性。PI建议解决上述限制，并创建具有显著性能增强和大幅尺寸和成本降低的新型NMR系统。为此，PI计划将集成电路（IC）技术系统地引入NMR领域。IC技术可能会给NMR系统的两个主要部件--NMR线圈和收发器的设计带来变革性的变化。更具体地说，PI将研究以下4个领域：1）PI计划通过开发包含大型收发器阵列和平面微线圈的集成探头来增加NMR光谱的吞吐量，以便可以同时分析许多样品; 2）PI旨在通过开发高灵敏度的收发器IC芯片和小型但均匀的磁体来创建微型NMR光谱系统，该项目将通过一种新型的混合匀场技术来实现; 3）该项目负责人将研究宽带集成收发器和线圈，以开发一种基于小型高精度、高空间分辨率NMR的磁场传感器; 4）该项目负责人建议通过设计一种新型的多通道收发器IC和多层微线圈阵列来创建一种移动的单面NMR系统。更广泛的影响。所提出的研究课题如果成功，将对核磁共振领域及其广泛的应用领域带来重大影响。例如，核磁共振波谱学的吞吐量增加将允许快速筛选组合库并加速药物发现过程;微型波谱学系统将使核磁共振波谱能够在小型实验室工作台上和实地测量;低成本核磁共振磁力计将使高分辨率磁场传感的有用性得到广泛利用;而集成的灵敏的单侧NMR系统将使得能够以减少的实验时间对任何任意对象进行移动的筛选。除了研究，PI计划积极参与当地产业的教学和研究，开发有效的教学风格，并使用最先进的信息技术进行创新教育。PI还将继续促进女性和少数民族学生在工程和达到

CAREER: Combining Nuclear Magnetic Resonance with Integrated Circuit TechnologyNan Sun (The University of Texas at Austin)Intellectual Merit. Nuclear magnetic resonance (NMR) is a resonance interaction between atomic nuclei and a radio-frequency magnetic field. It finds a broad array of applications in chemistry, biology, physics, medicine, and material science. Despite its versatility and enormous contributions, existing NMR systems have the constraints of limited sensitivity, low throughput, and long experiment time. In addition, they are bulky, heavy, and expensive. These drawbacks have limited their capability and accessibility. The PI proposes to address the aforementioned limitations and create novel NMR systems with significant performance enhancement and substantial size and cost reduction. To this end, the PI plans to systematically introduce integrated circuit (IC) technology to the field of NMR. IC technology can potentially bring transformational change to the design of NMR coil and transceiver, which are two main components of an NMR system. More specifically, the PI will investigate the following 4 areas: 1) the PI plans to increase the throughput of NMR spectroscopy by developing an integrated probehead that contains a large array of transceivers and planar microcoils, so that many samples can be analyzed simultaneously; 2) the PI aims to create a miniature NMR spectroscopy system by developing a highly-sensitive transceiver IC chip and a small but homogeneous magnet, made possible by a novel hybrid shimming technique; 3) the PI will study wideband integrated transceivers and coils to develop a miniature high-accuracy high-spatial-resolution NMR-based magnetic field sensor; 4) the PI proposes to create a mobile single-sided NMR system by designing a novel multichannel transceiver IC with a multilayer microcoil array. Broader Impact. The proposed research topics, if successful, will bring major impacts to the NMR field and its broad application fields. For example, an increased throughput for NMR spectroscopy will allow fast screening of combinatorial libraries and accelerate the drug discovery process; a miniature spectroscopy system will enable NMR spectra to be measured on small lab benches and in the field; a low-cost NMR magnetometer will make the usefulness of high-resolution magnetic-field sensing widely accessible; and an integrated sensitive single-sided NMR system will make possible mobile screening of any arbitrary object with reduced experiment time. In addition to the research, the PI plans to actively involve local industry in both teaching and research, develop effective teaching styles, and use state-of-the-art information technology for innovative education. The PI will also continue promoting female and minority students in engineering and reach o