Planning Grant: I/UCRC for Mid-Infrared MEdical Systems

1266294普林斯顿大学；该中心由普林斯顿大学领导，将专注于开发新的中红外技术的医疗应用。该中心的临床研究合作伙伴是克利夫兰诊所。拟建的MIMES中心计划建立长期的大学与临床行业合作伙伴关系，致力于研究和开发用于医疗应用的中红外光子技术工程系统。在医疗应用中使用特定波长的中红外激光器时，还存在尚未开发的机会。首先，生物和生理化合物，如葡萄糖、溶解的血气或蛋白质及其与癌症有关的畸形形式，在中红外光谱范围内具有独特的光谱特征。其次，呼吸成分作为健康、疾病控制或药物使用监测的生物标志物的重要性正在迅速增加；它们可以被现在唯一可用的快速时间分辨中红外传感器快速探测到。最后，特定的组织可以凝固、消融，或者使用高功率激光在特定的波长针对蛋白质、脂质或水进行更安全、更少损害周围组织的操作。同样，对新的诊断技术和技术的需求也很大，这些技术可以促进新的医学研究，并开发新的、快速的和/或非侵入性的诊断工具。该中心将在中红外光子学和生物医学工程与诊断两个快速发展的前沿研究领域的交叉点运营，并在长期的大学-临床行业合作伙伴关系下将它们结合在一起。必要的结果是新的生物医学诊断工具，开发如此接近工业现实和理解，使新的发现，知识和原型最迅速地转化为市场和社会，为所有人提供更好的短期和长期医疗保健。MIMES将主要与对工业研发和工业职业有明确兴趣的研究生和大四本科生进行研究。这一重点，加上全面的招聘和指导计划，以及强大的行业参与，将促进多元化，训练有素，具有全球竞争力的毕业生群体的发展，为现实世界，应用，生物医学和光子工程领域的领导做好准备。

1266294 Princeton University; Claire Gmachi The proposed center, led by Princeton University, will focus on developing the medical applications of new mid-infrared technologies. The clinical research partner for the proposed center is the Cleveland Clinic. The proposed center for MIMES plans to form long-term universityclinicindustry partnerships dedicated to the research and development of engineering systems employing mid-infrared photonic technologies for medical applications. As yet un-exploited opportunities present themselves when using mid-infrared lasers at specific wavelengths for medical applications. First, biological and physiological compounds, such as glucose, dissolved blood gases, or proteins and their malformed cancer-implicated forms have characteristic spectroscopic features in the mid-infrared spectral range. Next, breath constituents are rapidly gaining in importance as bio markers for health, disease-control, or drug-use monitoring; they can be detected rapidly by the only-now becoming available fast time-resolved mid-infrared sensors. Finally, specific tissue can be coagulated, ablated, and otherwise manipulated more safely and less damaging to surrounding tissue with the use of high-power lasers at wavelengths specifically targeting proteins, lipids, or water. Similarly, the needs are great for new Diagnostics techniques and technologies that enable new medical research, and develop new, fast and/or non-invasive diagnostics tools. The proposed center will operate at the intersection of two rapidly advancing, cutting-edge research fields mid-infrared photonics and bio-medical engineering and diagnostics and joins them together under the umbrella of long-term universityclinicindustry partnership. The necessary outcomes are new bio-medical diagnostics tools, developed so close to industrial reality and understanding to enable a most speedy translation of the new discoveries, knowledge, and prototypes into the marketplace and society, providing better healthcare in both the short and long-term for all. MIMES will conduct research primarily with graduate students and senior undergraduate students who have clear interests in industrial R&D and careers in industry. This focus, together with a comprehensive recruiting and mentoring plan with strong industry involvement will foster the development of a diverse, superbly trained, and globally competitive group of graduates for a workforce that is ready to assume leadership in real-world, applied, bio-medical and photonic engineering.