Molecular mechanisms of two-component signal transduction in bacteria

本研究的重点是细菌中传递信号以引起对环境刺激的预期反应的蛋白质复合物。像细胞中的许多动态过程一样，信号传导需要具有灵活性的蛋白质，因此可以抵抗使用晶体学进行高分辨率结构分析。我们将利用澳大利亚同步加速器和OPAL研究堆的新研究基础设施来克服这些系统灵活性的挑战。我们将研究的蛋白质在人类中没有发现，因此我们的研究将为设计抗细菌感染的新型抗生素提供重要的潜在靶点结构数据。

The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcome the challenges of flexibility in these systems. The proteins we will study are not found in humans, and hence our research will provide important structural data on potential targets for the design of novel antibiotics to fight bacterial infection.