Multiscale Materials in the Study and Treatment of Cancer

ID: MPS/DMR/BMAT(7623) 1340361 PI: Peyton， Shelly ORG：马萨诸塞大学：癌症研究和治疗中的多尺度材料技术部分：这是一份部分支持研讨会的提案，该研讨会将与2013年秋季在波士顿举行的材料研究学会（MRS）会议一起举行。仿生表面，纳米颗粒，甚至大型三维支架都能够捕捉某些生物系统的化学和物理特性，从纳米级（蛋白质和药物载体的大小），到微米级（模拟整个细胞），再到厘米级（模拟组织）。这种仿生方法的目的是在早期阶段检测侵入性疾病，在复杂的致密组织中识别和成像其位置，识别新的药物靶点，并将治疗或造影剂输送到特定区域。与所有新的生物医学工具一样，这些材料的独特性质（尺寸，拓扑结构，功能部分，力学和化学）的变化直接影响它们与生物介质和周围环境的相互作用。将强调控制设计和制造以及随后表征材料的重要性。非技术部分：本次研讨会汇集了一组国际研究人员在功能材料的合成，表面化学/涂层和靶向剂的鉴定，分享他们的发现和见解，从不同的角度。8名新的和/或年轻的研究人员将获得500美元的旅行奖励。获奖者将由研讨会指导委员会根据与会者提出的演讲摘要选出。

ID: MPS/DMR/BMAT(7623) 1340361 PI: Peyton, Shelly ORG: University of MassachusettsTitle: Multiscale Materials in the Study and Treatment of CancerTechnical Part: This a proposal for partial support of a symposium to be held in conjunction with the Fall 2013 Materials Research Society (MRS) conference in Boston. Biomimetic surfaces, nanoparticles, and even large three-dimensional scaffolds are able to capture the chemical and physical properties of certain biological systems, from nanometers (size of proteins and drug carriers), to microns (mimicking whole cells), to centimeters in length (modeling tissues). This biomimetic approach aims to detect invasive disease at early stages, to identify and image its location within complex, dense tissues, to identify novel drug targets, and to deliver therapeutics or contrast agents to a specific region. As with all new biomedical tools, variations in the unique properties of these materials (size, topology, functional moieties, mechanics, and chemistry) directly impact their interaction with the biological medium and surrounding environment. The importance of controlled design and fabrication and subsequent characterization of the materials will be emphasized. Non-Technical Part: This symposium brings together an international group of investigators in the synthesis of functional materials, surface chemistry/coatings, and identification of targeting agents to share their findings and insights from a variety of perspectives. The attendance of eight new and/or young investigators will be supported by $500 travel awards. Awardees will be selected by the symposium steering committee based on the abstracts of presentations proposed by attendees.