2024 Signal Transduction in Engineered Extracellular Matrices Gordon Research Conference and Seminar; Southern New Hampshire University, Manchester, New Hampshire; 20-26 July 2024

该奖项将支持2024年工程细胞外基质戈登研究会议和研讨会的信号转导;南新罕布什尔州大学，曼彻斯特，新罕布什尔州; 2024年7月20日至26日，它建立在以前的戈登研究会议（GRC）和戈登研究研讨会（GRS）的信号转导工程细胞外基质（STEEM）探索将定义下一代生物学，疾病建模和治疗学工程微环境未来十年工作的问题。会议的主题包括该领域如何将联合收割机力学和分子报告员结合起来，创造活的/动态的材料;开发能够理解细胞异质性和细胞死亡机制的生物教学材料;利用多尺度建模和系统生物学来预测材料和细胞的共同进化;并确定性别和血统对细胞-细胞外基质（ECM）信号传导的影响。在过去的四分之一世纪中，GRC和GRS的信号转导工程细胞外基质（STEEM）已成为首要场所，分享和讨论在ECM科学和工程的前沿发展。2024年GRC的目标包括：（i）成为一个论坛，让不同和互补背景的研究人员自由交流信息和想法，讨论材料和细胞界面的新兴技术。(ii)通过让他们在鼓励合议互动的环境中接触新的和令人兴奋的想法和机会，支持各种年轻和早期职业调查员。(iii)汇集所有经验水平的科学家，从实习生到高级科学家，并代表不同的专业知识和专业设置领域，从学术实验室到国家实验室到小型和大型生物技术和制药公司，以促进有意义的，长期的合作和（iv）鼓励持久的合议互动和不同领域的年轻，职业中期和高级研究人员之间的合作。该会议将扩大来自不同受众的参与，并将为早期职业科学家和历史上在该领域代表性不足的科学家提供网络机会。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award will support the 2024 Signal Transduction in Engineered Extracellular Matrices Gordon Research Conference and Seminar; Southern New Hampshire University, Manchester, New Hampshire; 20-26 July 2024, which builds on prior Gordon Research Conferences (GRC) and Gordon Research Seminars (GRS) on Signal Transduction by Engineered Extracellular Matrices (STEEM) to explore questions that will define the next decade of work in engineered microenvironments for next-generation biology, disease modeling, and therapeutics. Conference session topics include how the field can combine mechanics and molecular reporters to create living/dynamic materials; develop bio-instructive materials capable of understanding cell heterogeneity and cell death mechanisms; exploit multi-scale modeling and systems biology to predict material and cell coevolution; and determine the influence of sex and ancestry on cell-extracellular matrix (ECM) signaling.Over the past quarter-century, the GRC and GRS on Signal Transduction by Engineered Extracellular Matrices (STEEM) has served as the premier venue for sharing and discussing cutting-edge developments in ECM science and engineering. The objectives of the 2024 GRC include: (i) Be a forum in which information and ideas are freely exchanged between researchers of diverse and complementary backgrounds to discuss the emerging technologies at the interface of materials and cells. (ii) Support a diverse set of young and early career investigators by exposing them to new and exciting ideas and opportunities in an environment that encourages collegial interactions. (iii) Bring together scientists across all experience levels, from trainees to senior scientists, and represent diverse fields of expertise and professional settings, from academic labs to national labs to small and large biotechnology and pharmaceutical companies, to foster meaningful, long-lasting collaborations and (iv) Encourage lasting collegial interactions and initiation of collaborations between young, mid-career, and senior investigators of diverse fields. The conference will broaden participation from diverse audiences and will provide networking opportunities to both early career scientists and scientists historically underrepresented in the field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.