I-Corps: Multiplexed Diagnostic Platform for Rapid Diagnostics

目前诊断领域的商业仪器在样本到答案系统中通常缺乏一个或多个属性，具体地说：吞吐量、多路传输、灵敏度、快速回答和低成本。这项拟议的技术试图开发一个诊断平台，以解决目前现有技术中的关键弱点。提出的诊断平台是基于一种名为干涉反射成像传感器(IRIS)的光学检测方法。IRIS已在临床相关水平上实现了全血和血清中单病毒和单分子(蛋白质和核酸)的检测，该技术为多样本对答案的诊断测试提供了一种交钥匙解决方案。这项自动化技术可以直接检测与临床相关的病毒，而不需要第二个标签或标记。人们认为，拟议的办法可以与其他制度相竞争(从根本上更简单，降低仪器和消耗品的成本，允许对消耗品和仪器进行有竞争力的定价)。除了该系统的纯经济性外，拟议的技术还将有助于以最小的外形系数进行检测，并将浪费降至最低。最后，非破坏性传感技术允许存储样品，以便在需要时进行进一步测试。

Current commercial instruments in the diagnostic field usually lack one or more attributes in sample-to-answer systems, specifically: throughput, multiplexing, sensitivity, fast time to answer, and low-cost. The proposed technology attempts to develop a diagnostic platform that will address the key weaknesses in currently available technologies. The proposed diagnostic platform is based on an optical detection method termed Interferometric Reflectance Imaging Sensor (IRIS). IRIS has demonstrated single virus and single molecule (both protein & nucleic acids) detection in whole blood and serum at clinically relevant levels.The proposed technology provides a turn-key solution for multiplexed sample-to-answer diagnostic tests. This automated technology can detect clinically relevant virus directly without a secondary tag or marker. It is believed that the proposed approach can be competitive with other systems (fundamentally simpler, reducing the costs of the instrument and consumable, allowing for competitively pricing the consumable and instrument). In addition to the pure economics of the system, the proposed technology will help perform detection in a small form-factor with minimal waste. Finally, the non-destructive sensing techniques allow storage of samples for further testing if desired.