Scope and Applications of Amide Ligation of Hydroxyamines

有了这个新的奖项，化学合成计划支持加州大学河滨分校的Michael C.Pirrung教授进行一个项目，研究将氨基酸添加到多肽链上的反应，从而延长多肽链。在这些反应中将使用三种不同的氨基酸来构建肽链。这个项目的重点是拓宽可用于构建多肽和蛋白质的方法。这种反应在有机化学和生物化学的各个领域都具有深远的重要性。因此，这些方法将扩大生物医学科学中广泛研究人员的合成工具箱。该项目还将为学生提供有机合成和多肽化学方面的培训，从本科生到博士后，包括那些来自历史上在科学中代表性较低的群体的学生。该项目将研究丝氨酸和温和激活的C-末端多肽酯之间的多肽键形成反应。这些反应将扩展到苏氨酸和高丝氨酸，将扩大多肽形成反应的范围，并有助于缓解浓度和可扩展性的问题。该方法的可行性将通过合成自然产生的多肽序列进行测试。

With this New award, the Chemical Synthesis Program supports Professor Michael C. Pirrung of the University of California-Riverside in a project investigating reactions that add an amino acid to a peptide chain, thus extending the chain. Three different amino acids will be employed in these reactions, which build peptide chains. This project focuses on broadening the methods available for building peptides and proteins. Such reactions are of far reaching importance in diverse areas of organic and biological chemistry. Hence, these methods will expand the synthetic toolboxes of a wide range of researchers in the biomedical sciences. This project will also provide training in organic synthesis and peptide chemistry to students, from undergraduates to post-doctorals, including those from groups historically underrepresented in the sciences.The project will study peptide bond forming reactions between serine and mildly activated C-terminal peptide esters. These reactions, which will be extended to threonine and homoserine, will expand the scope of peptide forming reactions and help to alleviate problems of concentration and scalability. The viability of the method will be tested through the synthesis of naturally occurring peptide sequences.