MRI: Acquisition of High Performance Liquid Chromatography Tandem Mass Spectrometry Instrumentation to Support Research and Undergraduate Education in Southern Colorado

从主要研究仪器计划（MRI）和化学研究仪器计划（CRIF）的支持下，来自科罗拉多大学科罗拉多斯普林斯分校的Janel Owens教授将获得液相色谱仪，串联质谱仪（LCMS/MS）。一般来说，质谱（MS）是用于识别和表征嵌入复杂基质中的少量化学物质的关键分析方法之一。在典型的实验中，组分流入质谱仪，在那里它们被电离成母离子及其碎片离子，并测量它们的质量。以串联模式排列的腔室提供更高程度的分离。这种高灵敏度的技术可以检测和确定复杂混合物中分子的结构。带有液相色谱仪的仪器通过在化合物到达质谱仪之前分离化合物的混合物来提供额外的结构鉴定能力。作为一个主要的本科院校，教师在科罗拉多大学在科罗拉多泉拥抱本科研究经验作为他们的研究活动的最重要的成果之一。拟议的仪器将直接影响大量的本科生在三年的项目期间的研究经验，以及更多的在未来几年。该仪器将由NSF资助的REU项目的参与者使用，并将参与绿色化学研究，邻近的科罗拉多学院的学生也将使用该仪器。该奖项旨在加强各级研究和教育，特别是在以下领域：（a）调查环境和食品样品中的四溴双酚A（TBBPA）及其衍生物;（B）对科罗拉多疑似药物相关死亡的死后脑组织进行毒理学分析;（c）合成和评价用于治疗非洲人锥虫病的新的异羟肟酸系列;（d）研究氟化抗疟类似物的微波辅助合成;以及（e）调查和量化环境样本中的工程纳米材料。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Janel Owens from University of Colorado at Colorado Springs will acquire a liquid chromatograph, tandem mass spectrometer (LCMS/MS). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex matrices. In a typical experiment, the components flow into a mass spectrometer where they are ionized into the parent ion and its fragment ions and their masses are measured. The chambers aligned in a tandem mode provide a higher degree of separation. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. As a primarily undergraduate institution, the faculty at the University of Colorado at Colorado Springs embraces undergraduate research experiences as one of the most important outcomes of their research activities. The proposed instrument will directly impact the research experiences of a large number of undergraduate students within the three-year project period, and many more in years to come. The instrument will be used by participants in an NSF funded REU program and will be involved in green chemistry research and also by students at neighboring Colorado College.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) investigating tetrabromobisphenol-A (TBBPA) and derivatives in environmental and food samples; (b) toxicological analysis of postmortem brain tissue in suspected drug-related deaths in Colorado; (c) synthesizing and evaluating a new hydroxamic acid series for the treatment of Human African Trypanosomiasis; (d) investigating microwave-assisted synthesis of fluorinated antimalarial analogues; and (e) investigating and quantifying engineered nanomaterials in environmental samples.