Catalytic Synthesis via C-C Cleavage

通过这一奖项，化学部门的化学催化项目资助了堪萨斯大学的Jon A. Tunge教授，以开发从常见的碳-碳键中获取反应性中间体的策略，并利用这些反应性中间体来解决合成中的挑战。这项工作的更广泛影响包括发展对环境友好的催化合成。拓展项目包括在Instagram上提供有机化学卡片，并通过周末访问招募代表性不足的学生。访问周末教育未来的学生在堪萨斯大学正在进行的化学，并培训学生申请研究生院的最佳做法。一个研究重点是通过脱羧从廉价的羧酸催化获得活性亲核试剂和有机金属。目前的方法通常通过在高碱性条件下形成化学计量有机金属或使用高能还原金属来获得相关的反应中间体。所开发的脱羧偶联物比传统的方法更环保，并且由于反应条件温和，更适用于合成。Tunge教授也在开发脱酰基偶联，在交叉偶联反应中直接使用酮类。

With this award, the Chemical Catalysis Program of the Chemistry Division is funding Professor Jon A. Tunge of the University of Kansas to develop strategies to access reactive intermediates from common carbon-carbon bonds and utilize those reactive intermediates to address challenges in synthesis. The broader impacts of the work include developing environmentally friendly catalytic synthesis. Outreach programs include providing organic chemistry flash cards on Instagram and recruiting underrepresented students through a visitation weekend. The visitation weekend educates prospective students on ongoing chemistry at the University of Kansas and trains the students on best practices for applying to graduate schools.One research focus is on catalytically accessing reactive nucleophiles and organometallics from inexpensive carboxylic acids via decarboxylation. Current methods typically access related reactive intermediates through formation of stoichiometric organometallics under highly basic conditions or using high energy reduced metals. The decarboxylative couplings developed are more environmentally benign than classic methods and are more applicable in synthesis due to the mild reaction conditions. Professor Tunge is also developing deacylative couplings that directly employ ketones in cross-coupling reactions.