Gene Drives: A Deliberative Workshop to Develop Frameworks for Research and Governance February 24-26, 2016

普通观众摘要该奖项为2015-2016年初冬为期三天的研讨会提供资金。会议的主题是基因驱动的治理。基因驱动是正在开发的第二代基因工程技术的子集，目的是将合成的基因结构转移到野生动物种群中，以保护、抑制或消除它们，例如抑制传播疟疾和登革热的蚊子。来自四个领域的专家将参加研讨会：遗传学和分子生物学、生态学和生态建模、政治经济学和STS(包括伦理学)。国际和平协会计划在这些领域有平等的代表性；专家将包括学术界成员、从业者和来自政府、非政府组织和工业界的专家。研讨会的结构将设计成让与会者共同努力，以产生对未来关于基因驱动的决策和政策制定有用的分析和总结。讲习班结束后，论文将定稿，以便在特别期刊版上发表。项目委员会将发表一篇总结文章，对案例研究中的问题和系统图进行比较，并总结研讨会的主要发现。计划委员会还将起草一篇较短的文章提交给备受瞩目的场所，如《自然》或《科学》评论。技术总结拟议的研讨会将产生基因驱动的类型学，以进行更微妙和富有成效的关于治理的对话。具体地说，与会者将制定一份关于基因驱动的技术、目的和背景的类型学草案，以及三个关键领域的问题和研究需求的框架：生态风险分析、政治经济学分析(包括治理制度)和伦理分析。为了涵盖一系列技术、目的和问题，但又足够具体，以便进行富有成效的对话，将使用三个案例研究来预测与基因驱动相关的社会、生态、经济和伦理问题。将通过广泛的多学科参与和对案例及其所在系统的思考来实现自然科学和社会科学的融合。协作系统映射将被用作协助整合自然、社会和伦理变量的工具，因为它已被证明有效地创造了一种环境，在这种环境中，可以更好地看到和理解复杂性和不确定性，参与者更愿意接受不同的观点。研讨会的主题、方法和成果的结合使其独一无二，它将有助于加深对社会背景下基因驱动的智力理解。

General Audience SummaryThis award provides funding for a workshop that is to occur over three full days in the early winter of 2015-2016. The topic of the conference is the governance of gene drives. Gene drives are a subset of second generation genetic engineering technologies that are being developed with the aim of moving synthetic gene constructs into wild animal populations to protect, suppress or eliminate them, such as the suppression of mosquitoes that transmit malaria and dengue. Experts from four areas will participate in the workshop: Genetics and molecular biology, ecology and ecological modeling, political economy, and STS (including ethics). The PI plans for there to be equal representation across these areas; experts will include members of academia, practitioners and experts from government, NGOs, and industry. The structure of the workshop will be designed to engage participants in working together to generate analyses and summaries useful for future decision and policy making about gene drives. Following the workshop, papers will be finalized for publication in a special journal edition. A summary article will be published by the program committee that compares issues and system maps across the case studies and summarizes the key findings of the workshop. The program committee will also draft a shorter piece sub mitted for a high profile venue, such as a Nature or Science commentary.Technical Summary The proposed workshop will produce a typology of gene drives for more nuanced and productive conversations about governance. Specifically, participants will develop a draft typology of technologies, purposes, and contexts of gene drives, and a framework of issues and research needs for three key areas: ecological risk analysis, political economy analysis (including governance regimes), and ethical analysis. In order to cover a range of technologies, purposes, and issues, but yet be specific enough for productive dialogue, three case studies will be used to anticipate the social, ecological, economic, and ethical issues associated with gene drives. Integration of the natural and social sciences will be achieved through broad multidisciplinary participation and thinking about the cases and the systems in which they are embedded. Collaborative systems mapping will be used as a tool to assist in the integration of natural, social, and ethical variables, as it has been shown to be effective in creating an environment where complexities and uncertainties can be better seen and understood , and where participants are more willing to open up to alternative perspectives. The combination of the topic, approach, and outputs of the workshop make it unique, and it will contribute to deeper intellectual understanding of gene drives in societal contexts.